SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KHP_A_PARA1606_1 (16S RIBOSOMAL RNA 30S RIBOSOMAL PROTEIN S9 30S RIBOSOMAL PROTEIN S10)	5t0i	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 (Homo sapiens)	3 / 3	TYR d 74 ARG d 65 SER d 70	None	0.84A	4khpI-5t0id: undetectable 4khpJ-5t0id: undetectable	4khpI-5t0id: 17.17 4khpJ-5t0id: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_A_PFLA510_1 (PROTON-GATED ION CHANNEL)	5t0i	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 (Homo sapiens)	5 / 9	ILE d 182 ALA d 179 ILE d 178 ALA d 194 LEU d 198	None	0.98A	5mvmA-5t0id: 3.2 5mvmE-5t0id: undetectable	5mvmA-5t0id: 12.50 5mvmE-5t0id: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_E_PFLE409_1 (PROTON-GATED ION CHANNEL)	5t0i	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 (Homo sapiens)	5 / 10	ALA d 194 LEU d 198 ILE d 182 ALA d 179 ILE d 178	None	0.98A	5mvmD-5t0id: 3.1 5mvmE-5t0id: undetectable	5mvmD-5t0id: 12.50 5mvmE-5t0id: 12.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4KHP_A_PARA1606_1","16S RIBOSOMAL RNA;30S RIBOSOMAL PROTEIN S9;30S RIBOSOMAL PROTEIN S10","5t0i","26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8","Homo sapiens",3,"TYR d  74;ARG d  65;SER d  70","None","0.84A","4khpI-5t0id:undetectable;4khpJ-5t0id:undetectable","4khpI-5t0id:17.17;4khpJ-5t0id:14.61"],["5MVM_A_PFLA510_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","5t0i","26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8","Homo sapiens",5,"ILE d 182;ALA d 179;ILE d 178;ALA d 194;LEU d 198","None","0.98A","5mvmA-5t0id:3.2;5mvmE-5t0id:undetectable","5mvmA-5t0id:12.50;5mvmE-5t0id:12.50"],["5MVM_E_PFLE409_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","5t0i","26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8","Homo sapiens",5,"ALA d 194;LEU d 198;ILE d 182;ALA d 179;ILE d 178","None","0.98A","5mvmD-5t0id:3.1;5mvmE-5t0id:undetectable","5mvmD-5t0id:12.50;5mvmE-5t0id:12.50"]]