SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		5 / 12 ARG A  73
LEU A  39
LEU A 167
ILE A 171
ALA A  61
 None
 0.94A 2bxpA-5t0zA:
undetectable		 2bxpA-5t0zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 5 LEU A  39
LEU A 167
ILE A 171
ALA A  61
 None
 0.63A 2i2zA-5t0zA:
undetectable		 2i2zA-5t0zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 8 THR A  59
VAL A  58
PHE A 131
ALA A 129
 None
 0.68A 2ij7C-5t0zA:
undetectable		 2ij7C-5t0zA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 7 ALA A  51
ALA A  55
THR A  59
LEU A 133
 None
 0.94A 2wx2A-5t0zA:
undetectable		 2wx2A-5t0zA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 5 ASN A  44
ALA A  52
ALA A  51
ARG A  54
 None
 1.29A 3kp2B-5t0zA:
undetectable		 3kp2B-5t0zA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 8 ALA A  51
ALA A  55
THR A  59
LEU A 133
 None
 0.84A 3l4dD-5t0zA:
undetectable		 3l4dD-5t0zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		4 / 7 LEU A  39
LEU A 133
ILE A 136
VAL A 143
 None
 0.86A 4ojbA-5t0zA:
undetectable		 4ojbA-5t0zA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 5t0z LIPOPROTEIN,
PUTATIVE
(Geobacter
metallireducens) 		3 / 3 GLU A 137
ARG A 107
TYR A 108
 None
 0.62A 5trqB-5t0zA:
undetectable		 5trqB-5t0zA:
18.88