SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 306
ALA A 284
ALA A 280
VAL A 272
GLN A 303
 None
None
None
None
IOD  A 501 ( 4.4A)
 1.25A 1hbpA-5t12A:
undetectable		 1hbpA-5t12A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		5 / 11 ALA A 183
PHE A 323
ILE A 366
PRO A 367
GLY A 345
 None
 1.45A 3bpxA-5t12A:
undetectable
3bpxB-5t12A:
undetectable		 3bpxA-5t12A:
20.39
3bpxB-5t12A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 361
MET A 360
ALA A 363
TYR A 245
 None
 1.06A 4lb2A-5t12A:
undetectable		 4lb2A-5t12A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 212
LEU A 309
ILE A 276
LEU A 254
MET A 194
 None
 1.19A 5og9A-5t12A:
undetectable		 5og9A-5t12A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 338
LEU A 343
MET A 360
GLN A 303
 None
None
None
IOD  A 501 ( 4.4A)
 1.23A 5uc3A-5t12A:
undetectable		 5uc3A-5t12A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 262
ARG A 211
GLU A 208
LEU A 306
 None
 1.07A 5umwB-5t12A:
undetectable
5umwE-5t12A:
undetectable		 5umwB-5t12A:
14.75
5umwE-5t12A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 279
LEU A 216
LEU A 248
VAL A 272
 None
 1.24A 5xxiA-5t12A:
undetectable		 5xxiA-5t12A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA A 353
VAL A 361
ALA A 177
VAL A 346
GLY A 388
 None
 1.01A 6bklA-5t12A:
undetectable
6bklB-5t12A:
undetectable
6bklC-5t12A:
undetectable
6bklD-5t12A:
undetectable		 6bklA-5t12A:
8.80
6bklB-5t12A:
8.80
6bklC-5t12A:
8.80
6bklD-5t12A:
8.80