SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 ARG A 206
SER A 172
GLY A 118
THR A 117
 None
None
None
73R  A1201 (-3.3A)
 1.24A 2f7fA-5t1aA:
undetectable		 2f7fA-5t1aA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 TYR A1161
GLU A1011
ASP A1020
 None
 0.86A 3bxoA-5t1aA:
undetectable		 3bxoA-5t1aA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 11 TYR A1018
GLU A1011
PHE A1104
ASP A1070
ASP A1020
 None
 1.33A 3id5B-5t1aA:
undetectable		 3id5B-5t1aA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 11 TYR A1018
GLU A1011
PHE A1104
ASP A1070
ASP A1020
 None
 1.33A 3id5F-5t1aA:
undetectable		 3id5F-5t1aA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 GLY A 127
GLY A 126
SER A  87
TRP A 165
 None
 0.81A 3o9mB-5t1aA:
undetectable		 3o9mB-5t1aA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ILE A1058
ALA A1042
LEU A1046
LEU A1066
ALA A1063
 None
 1.00A 3ozvB-5t1aA:
undetectable		 3ozvB-5t1aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 5 ASP A  88
ASN A 301
ILE A 131
VAL A 251
 None
 1.25A 4hytA-5t1aA:
undetectable		 4hytA-5t1aA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A  49
TRP A  98
PHE A 194
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
 0.98A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
73R  A1201 (-3.4A)
 0.55A 4mbsA-5t1aA:
37.0		 4mbsA-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 TYR A  49
TRP A  98
PHE A 194
THR A 267
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
 1.00A 4mbsB-5t1aA:
37.6		 4mbsB-5t1aA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
THR A 267
GLU A 291
 73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
None
73R  A1201 (-3.4A)
 0.58A 4mbsB-5t1aA:
37.6		 4mbsB-5t1aA:
49.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 TYR A 222
THR A 135
ILE A 132
ILE A 131
ILE A 128
 None
 0.98A 5murE-5t1aA:
3.7		 5murE-5t1aA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 ARG A 232
LYS A 239
ARG A 313
 OLC  A1207 (-3.5A)
OLC  A1207 (-3.7A)
None
 1.31A 6c06D-5t1aA:
1.9		 6c06D-5t1aA:
undetectable