SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		3 / 3 TRP A  48
VAL A  91
TRP A  45
 None
None
GPE  A 402 (-3.2A)
 1.16A 1c4dC-5t1pA:
undetectable
1c4dD-5t1pA:
undetectable		 1c4dC-5t1pA:
5.60
1c4dD-5t1pA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 TRP A 339
ILE A 344
ASP A 210
ASN A 230
 None
None
GPE  A 402 (-3.7A)
None
 1.47A 1kiaD-5t1pA:
undetectable		 1kiaD-5t1pA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 THR A  51
ASP A  90
THR A 258
LEU A 287
GLY A 283
 None
 1.38A 1v8bA-5t1pA:
undetectable		 1v8bA-5t1pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 THR A  51
ASP A  90
THR A 258
LEU A 287
GLY A 283
 None
 1.39A 1v8bB-5t1pA:
undetectable		 1v8bB-5t1pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 ALA A 179
TRP A 328
LEU A 183
ALA A 182
LEU A 335
 None
 1.09A 1xdkA-5t1pA:
undetectable		 1xdkA-5t1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 11 LEU A 279
ALA A 274
ILE A 260
ALA A 130
ILE A 278
 None
 1.06A 2idwA-5t1pA:
undetectable		 2idwA-5t1pA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 GLN A 315
TYR A 316
TYR A 291
ILE A 306
 None
 1.21A 2ph9A-5t1pA:
undetectable
2ph9B-5t1pA:
undetectable		 2ph9A-5t1pA:
19.89
2ph9B-5t1pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 11 ALA A  30
ALA A 271
GLU A  33
GLY A  34
ILE A  61
 None
 1.12A 2x1lA-5t1pA:
undetectable		 2x1lA-5t1pA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 GLY A 157
ILE A 161
ARG A 205
GLN A 203
 None
 0.80A 2xrhA-5t1pA:
undetectable		 2xrhA-5t1pA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 9 ALA A 274
GLY A  89
ILE A 260
ALA A 130
ILE A 278
 None
 1.00A 3ektB-5t1pA:
undetectable		 3ektB-5t1pA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 VAL A 226
PHE A 197
ILE A 161
PHE A 196
 None
 0.91A 3owxB-5t1pA:
undetectable		 3owxB-5t1pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 SER A 255
ASP A  90
ASP A  67
ALA A 170
 None
None
GPE  A 402 ( 4.5A)
GPE  A 402 (-3.6A)
 1.40A 3uj6A-5t1pA:
undetectable		 3uj6A-5t1pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ASP A  65
SER A  64
TRP A  52
ASP A  43
 None
 1.48A 3w9tB-5t1pA:
undetectable		 3w9tB-5t1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ASP A  65
SER A  64
TRP A  52
ASP A  43
 None
 1.49A 3w9tC-5t1pA:
undetectable		 3w9tC-5t1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ASP A  65
SER A  64
TRP A  52
ASP A  43
 None
 1.49A 3w9tD-5t1pA:
undetectable		 3w9tD-5t1pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 ILE A  22
GLU A 276
PHE A 277
TYR A 112
 None
 0.99A 4a97D-5t1pA:
undetectable		 4a97D-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 6 GLU A 276
PHE A 277
TYR A 112
HIS A 299
 None
 1.20A 4a97E-5t1pA:
undetectable		 4a97E-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 GLU A 276
PHE A 277
TYR A 112
HIS A 299
 None
 1.13A 4a97J-5t1pA:
undetectable		 4a97J-5t1pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 11 LEU A 279
ALA A 274
GLY A  89
ILE A 260
ILE A 278
 None
 0.98A 4dqhA-5t1pA:
undetectable		 4dqhA-5t1pA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 6 THR A 150
PRO A 148
PHE A 196
PHE A 137
 None
 1.25A 4kf9A-5t1pA:
undetectable		 4kf9A-5t1pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 SER A  38
ASP A  65
GLU A  73
THR A  51
 None
None
GPE  A 402 ( 4.6A)
None
 1.10A 4lnwA-5t1pA:
undetectable		 4lnwA-5t1pA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		3 / 3 SER A 255
ASP A  90
ASP A  67
 None
None
GPE  A 402 ( 4.5A)
 0.92A 4mwzA-5t1pA:
undetectable		 4mwzA-5t1pA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ARG A 235
LEU A 232
PHE A 229
LEU A 311
 None
 1.23A 5iy5P-5t1pA:
undetectable
5iy5W-5t1pA:
undetectable		 5iy5P-5t1pA:
22.19
5iy5W-5t1pA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 6 LEU A 129
ILE A  88
THR A 259
TRP A  52
 None
 1.24A 5ljeA-5t1pA:
undetectable		 5ljeA-5t1pA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 TYR A 131
ILE A 278
ILE A  88
ILE A 260
ILE A 261
 None
 1.08A 5murE-5t1pA:
undetectable		 5murE-5t1pA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 THR A  51
ASP A  90
THR A 258
LEU A 287
GLY A 283
 None
 1.34A 5utuF-5t1pA:
undetectable		 5utuF-5t1pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 5 ARG A 235
LEU A 232
PHE A 229
LEU A 311
 None
 1.19A 5x1fC-5t1pA:
undetectable
5x1fJ-5t1pA:
undetectable		 5x1fC-5t1pA:
22.49
5x1fJ-5t1pA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 6 GLY A 164
ASN A 208
ASP A 165
SER A 167
 None
 1.20A 6dwdA-5t1pA:
undetectable
6dwdC-5t1pA:
undetectable		 6dwdA-5t1pA:
22.75
6dwdC-5t1pA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 11 ASP A 228
ALA A 136
TYR A 234
GLY A 231
ALA A  46
 None
 1.27A 6ieyA-5t1pA:
undetectable
6ieyB-5t1pA:
undetectable		 6ieyA-5t1pA:
24.38
6ieyB-5t1pA:
24.38