SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		4 / 8 ALA A  13
VAL A  87
VAL A 103
TYR A 195
 None
 0.83A 1epbB-5t1vA:
undetectable		 1epbB-5t1vA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 12 LEU A 141
ILE A 204
GLY A 213
VAL A 160
VAL A 219
 None
 0.95A 1vptA-5t1vA:
undetectable		 1vptA-5t1vA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 12 THR A  92
GLY A 102
PHE A 111
THR A 118
TYR A 144
 None
 1.39A 2axnA-5t1vA:
undetectable		 2axnA-5t1vA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 9 PHE A 111
THR A 113
VAL A 117
ALA A 121
LEU A 123
 None
 0.70A 2m9qA-5t1vA:
13.1		 2m9qA-5t1vA:
48.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 12 HIS A 116
VAL A 137
ASP A 140
GLY A 198
SER A 200
 None
 0.99A 3sueC-5t1vA:
3.6		 3sueC-5t1vA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 9 ILE A 212
TRP A 148
GLN A 161
LEU A 214
LEU A 141
 None
 1.29A 5fhzB-5t1vA:
undetectable		 5fhzB-5t1vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		5 / 10 ILE A 212
TRP A 148
GLN A 161
LEU A 214
LEU A 141
 None
 1.23A 5fhzC-5t1vA:
undetectable		 5fhzC-5t1vA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		4 / 5 HIS A 116
ALA A 197
SER A 200
TYR A 215
 None
 0.78A 5yodF-5t1vA:
12.5		 5yodF-5t1vA:
98.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		4 / 5 TYR A   9
ARG A  93
MET A  91
THR A  99
 None
 1.32A 5z86J-5t1vA:
undetectable		 5z86J-5t1vA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		4 / 6 TRP A 148
GLY A 209
ALA A 152
LEU A 150
 None
 0.99A 6fosA-5t1vA:
undetectable		 6fosA-5t1vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE
(Zika
virus) 		4 / 5 TYR A   9
ARG A  93
MET A  91
THR A  99
 None
 1.28A 6nknW-5t1vA:
undetectable		 6nknW-5t1vA:
12.09