SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		5 / 11 ILE A 216
LEU A 171
ILE A 202
PHE A 237
ILE A 249
 None
 1.04A 1dyrA-5t2hA:
undetectable		 1dyrA-5t2hA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		4 / 4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.26A 1xz1A-5t2hA:
undetectable		 1xz1A-5t2hA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		4 / 4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.25A 1xz3A-5t2hA:
undetectable		 1xz3A-5t2hA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		5 / 12 GLY A 260
ILE A  47
ILE A  60
ILE A  14
ALA A  21
 None
None
None
None
CA  A 401 (-4.6A)
 0.86A 2b60A-5t2hA:
undetectable		 2b60A-5t2hA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		5 / 12 LEU A  99
ALA A  19
GLY A  23
LEU A  49
ILE A  56
 None
 1.12A 3ku1G-5t2hA:
undetectable		 3ku1G-5t2hA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		3 / 3 LEU A  99
TRP A 170
GLY A 173
 None
 0.77A 3l35A-5t2hA:
undetectable
3l35H-5t2hA:
undetectable		 3l35A-5t2hA:
9.36
3l35H-5t2hA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		3 / 3 LEU A  99
TRP A 170
GLY A 173
 None
 0.77A 3l35B-5t2hA:
undetectable
3l35K-5t2hA:
undetectable		 3l35B-5t2hA:
9.36
3l35K-5t2hA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		5 / 12 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 401 (-4.6A)
None
 1.13A 3sudB-5t2hA:
undetectable		 3sudB-5t2hA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5t2h I-ONUI_E-HTCRA
(synthetic
construct) 		5 / 11 VAL A 252
PHE A 253
PHE A 237
GLY A 220
LEU A 171
 None
 0.99A 3t3rA-5t2hA:
undetectable		 3t3rA-5t2hA:
20.89