SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 195
ASP A 147
MET A 146
PRO A 145
 None
None
76R  A 301 ( 2.9A)
None
 1.40A 1ilqA-5t2kA:
undetectable
1ilqC-5t2kA:
undetectable		 1ilqA-5t2kA:
16.74
1ilqC-5t2kA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A  70
THR A 187
LEU A  71
LEU A  82
ILE A  74
 None
 1.31A 1kqwA-5t2kA:
undetectable		 1kqwA-5t2kA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.25A 1q23B-5t2kA:
undetectable		 1q23B-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.25A 1q23C-5t2kA:
undetectable		 1q23C-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 11 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.24A 1q23I-5t2kA:
undetectable		 1q23I-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.20A 1q23K-5t2kA:
undetectable		 1q23K-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		3 / 3 PHE A  17
TYR A  61
LEU A  99
 None
 0.68A 3keeB-5t2kA:
undetectable		 3keeB-5t2kA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.23A 3u9fI-5t2kA:
undetectable		 3u9fI-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.18A 3u9fJ-5t2kA:
undetectable
3u9fK-5t2kA:
undetectable		 3u9fJ-5t2kA:
19.22
3u9fK-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		5 / 10 PHE A  72
LEU A 237
VAL A 242
PHE A  40
VAL A  60
 None
 1.22A 3u9fR-5t2kA:
undetectable		 3u9fR-5t2kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 241
VAL A 248
HIS A 247
 None
 0.80A 6a5yD-5t2kA:
undetectable		 6a5yD-5t2kA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830
(Geobacillus
stearothermophil
us) 		4 / 5 GLU A  51
HIS A  58
LEU A  41
VAL A  44
 None
 1.10A 6bc9A-5t2kA:
undetectable		 6bc9A-5t2kA:
15.97