SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		5 / 11 ILE A 216
LEU A 171
ILE A 202
PHE A 237
ILE A 249
 None
 1.02A 1dyrA-5t2nA:
undetectable		 1dyrA-5t2nA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		5 / 12 GLY A 260
ILE A  47
ILE A  60
ILE A  14
ALA A  21
 None
None
None
None
CA  A 402 (-4.8A)
 0.80A 1sguB-5t2nA:
undetectable		 1sguB-5t2nA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		4 / 7 PHE A 200
LEU A 171
PHE A 181
VAL A 261
 None
 1.08A 1wrlA-5t2nA:
undetectable
1wrlB-5t2nA:
undetectable		 1wrlA-5t2nA:
13.85
1wrlB-5t2nA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		4 / 6 PHE A 181
GLN A 197
ASN A 184
LEU A 282
 None
 1.24A 2nyrA-5t2nA:
undetectable		 2nyrA-5t2nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		4 / 6 PHE A 200
GLN A 197
ASN A 184
LEU A 282
 None
 0.98A 2nyrA-5t2nA:
undetectable		 2nyrA-5t2nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		4 / 5 PHE A  45
PHE A  94
TRP A  64
GLY A  17
 None
 1.29A 2qmzA-5t2nA:
undetectable
2qmzB-5t2nA:
undetectable		 2qmzA-5t2nA:
22.80
2qmzB-5t2nA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		3 / 3 LEU A  99
TRP A 170
GLY A 173
 None
 0.82A 3l35B-5t2nA:
undetectable
3l35K-5t2nA:
undetectable		 3l35B-5t2nA:
10.27
3l35K-5t2nA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		5 / 12 LEU A 258
THR A 175
LEU A 168
LEU A 171
PHE A 181
 None
 1.37A 3n58A-5t2nA:
undetectable		 3n58A-5t2nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		3 / 3 LEU A 211
ARG A 207
MET A 138
 None
 0.99A 4m11C-5t2nA:
undetectable		 4m11C-5t2nA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		5 / 8 PHE A  45
TYR A 107
PHE A  94
TRP A  64
GLY A  17
 None
 1.48A 4qoiA-5t2nA:
undetectable
4qoiB-5t2nA:
undetectable		 4qoiA-5t2nA:
23.05
4qoiB-5t2nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5t2n I-ONUI_E-AG007820
(synthetic
construct) 		5 / 12 GLY A 201
PHE A 200
LEU A 215
VAL A 252
ILE A 249
 None
 1.40A 5tuiB-5t2nA:
undetectable		 5tuiB-5t2nA:
23.44