SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.18A 1xz1A-5t2oA:
undetectable		 1xz1A-5t2oA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.17A 1xz3A-5t2oA:
undetectable		 1xz3A-5t2oA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 8 ARG A 232
TRP A 234
HIS A 205
GLN A 204
 None
None
None
CA  A 401 ( 4.2A)
 1.49A 2vxaA-5t2oA:
undetectable
2vxaC-5t2oA:
undetectable
2vxaE-5t2oA:
undetectable		 2vxaA-5t2oA:
13.54
2vxaC-5t2oA:
13.54
2vxaE-5t2oA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 8 ARG A 232
TRP A 234
HIS A 205
GLN A 204
 None
None
None
CA  A 401 ( 4.2A)
 1.49A 2vxaA-5t2oA:
undetectable
2vxaB-5t2oA:
undetectable
2vxaK-5t2oA:
undetectable		 2vxaA-5t2oA:
13.54
2vxaB-5t2oA:
13.54
2vxaK-5t2oA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 8 ARG A 232
TRP A 234
HIS A 205
GLN A 204
 None
None
None
CA  A 401 ( 4.2A)
 1.50A 2vxaD-5t2oA:
undetectable
2vxaE-5t2oA:
undetectable
2vxaL-5t2oA:
undetectable		 2vxaD-5t2oA:
13.54
2vxaE-5t2oA:
13.54
2vxaL-5t2oA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 12 ASN A 228
ILE A 202
GLY A 179
LEU A 235
THR A 238
 None
 1.08A 3eeyA-5t2oA:
undetectable		 3eeyA-5t2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 12 ASN A 228
ILE A 202
GLY A 179
LEU A 235
THR A 238
 None
 1.05A 3eeyB-5t2oA:
undetectable		 3eeyB-5t2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 12 LEU A 258
THR A 175
LEU A 168
LEU A 171
PHE A 181
 None
 1.42A 3glqA-5t2oA:
undetectable		 3glqA-5t2oA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 12 LEU A 258
THR A 175
LEU A 168
LEU A 171
PHE A 181
 None
 1.45A 3n58D-5t2oA:
undetectable		 3n58D-5t2oA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 12 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 401 (-4.8A)
None
 1.10A 3sudB-5t2oA:
undetectable		 3sudB-5t2oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 6 LEU A  15
PHE A  45
ALA A  46
LEU A  57
 None
 0.97A 3t3zA-5t2oA:
undetectable		 3t3zA-5t2oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 6 LEU A  15
PHE A  45
ALA A  46
LEU A  57
 None
 0.95A 3t3zB-5t2oA:
undetectable		 3t3zB-5t2oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		4 / 6 LEU A  15
PHE A  45
ALA A  46
LEU A  57
 None
 0.96A 3t3zD-5t2oA:
undetectable		 3t3zD-5t2oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5t2o I-ONUI_E-AG011377
(synthetic
construct) 		5 / 9 LEU A  49
ARG A  80
PHE A  45
THR A  16
ASP A  20
 None
 1.30A 4drhE-5t2oA:
3.0		 4drhE-5t2oA:
15.75