SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EFJ_A_37TA502_1 (3,7-DIMETHYLXANTHINE METHYLTRANSFERASE)	5t2s	DDK KINASE REGULATORY SUBUNIT DBF4,SERINE/THREONIN E-PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	5 / 12	LEU A 214 PHE A 210 ILE A 172 SER A 124 ILE A 119	None	1.32A	2efjA-5t2sA: undetectable	2efjA-5t2sA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WQ4_B_ACTB403_0 (TRNA N6-ADENOSINE THREONYLCARBAMOYLTRA NSFERASE)	5t2s	DDK KINASE REGULATORY SUBUNIT DBF4,SERINE/THREONIN E-PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	3 / 3	ARG A 249 ASP A 250 ARG A 238	None GOL A 402 ( 2.9A) GOL A 402 (-3.8A)	0.69A	4wq4B-5t2sA: undetectable	4wq4B-5t2sA: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XR4_B_AG2B511_1 (HOMOSPERMIDINE SYNTHASE)	5t2s	DDK KINASE REGULATORY SUBUNIT DBF4,SERINE/THREONIN E-PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	3 / 3	VAL A 335 PHE A 271 ARG A 249	None	0.93A	4xr4B-5t2sA: undetectable	4xr4B-5t2sA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_H_CVIH301_1 (REGULATORY PROTEIN TETR)	5t2s	DDK KINASE REGULATORY SUBUNIT DBF4,SERINE/THREONIN E-PROTEIN KINASE RAD53 (Saccharomyces cerevisiae)	4 / 8	GLY A 154 ILE A 174 TRP A 202 ASP A 149	None	1.03A	5vlmH-5t2sA: undetectable	5vlmH-5t2sA: 21.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2EFJ_A_37TA502_1","3,7-DIMETHYLXANTHINE METHYLTRANSFERASE","5t2s","DDK KINASE REGULATORY SUBUNIT DBF4,SERINE\/THREONINE-PROTEIN KINASE RAD53","Saccharomyces cerevisiae",5,"LEU A 214;PHE A 210;ILE A 172;SER A 124;ILE A 119","None","1.32A","2efjA-5t2sA:undetectable","2efjA-5t2sA:21.23"],["4WQ4_B_ACTB403_0","TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE","5t2s","DDK KINASE REGULATORY SUBUNIT DBF4,SERINE\/THREONINE-PROTEIN KINASE RAD53","Saccharomyces cerevisiae",3,"ARG A 249;ASP A 250;ARG A 238","None;GOL A 402 ( 2.9A);GOL A 402 (-3.8A)","0.69A","4wq4B-5t2sA:undetectable","4wq4B-5t2sA:19.17"],["4XR4_B_AG2B511_1","HOMOSPERMIDINE SYNTHASE","5t2s","DDK KINASE REGULATORY SUBUNIT DBF4,SERINE\/THREONINE-PROTEIN KINASE RAD53","Saccharomyces cerevisiae",3,"VAL A 335;PHE A 271;ARG A 249","None","0.93A","4xr4B-5t2sA:undetectable","4xr4B-5t2sA:18.75"],["5VLM_H_CVIH301_1","REGULATORY PROTEIN TETR","5t2s","DDK KINASE REGULATORY SUBUNIT DBF4,SERINE\/THREONINE-PROTEIN KINASE RAD53","Saccharomyces cerevisiae",4,"GLY A 154;ILE A 174;TRP A 202;ASP A 149","None","1.03A","5vlmH-5t2sA:undetectable","5vlmH-5t2sA:21.72"]]