SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 178
LEU A 135
THR A 134
VAL A 196
 NAP  A 301 (-4.7A)
None
NAP  A 301 (-4.2A)
None
 1.08A 1ekjF-5t2uA:
2.9
1ekjG-5t2uA:
1.9		 1ekjF-5t2uA:
22.43
1ekjG-5t2uA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A   3
ALA A   8
LEU A   6
VAL A  10
 None
 1.12A 1sn5A-5t2uA:
undetectable		 1sn5A-5t2uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 234
TYR A 238
GLU A 155
 None
 0.79A 1vm1A-5t2uA:
undetectable		 1vm1A-5t2uA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  12
ARG A  37
ARG A  41
ASP A  59
ALA A  83
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.0A)
NAP  A 301 (-3.8A)
NAP  A 301 ( 3.7A)
 0.90A 2bm9A-5t2uA:
6.3		 2bm9A-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  12
ARG A  37
ARG A  41
ASP A  59
ASN A  82
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.0A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.4A)
 0.90A 2bm9B-5t2uA:
5.2		 2bm9B-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  12
SER A  21
ARG A  37
ASP A  59
ASN A  82
 NAP  A 301 (-3.3A)
None
NAP  A 301 (-3.5A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.4A)
 1.34A 2bm9B-5t2uA:
5.2		 2bm9B-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  12
ARG A  37
ASP A  59
ASN A  82
ALA A  83
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.8A)
NAP  A 301 (-3.4A)
NAP  A 301 ( 3.7A)
 1.01A 2bm9E-5t2uA:
5.1		 2bm9E-5t2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  12
ARG A  37
ARG A  41
ASP A  59
ALA A  83
 NAP  A 301 (-3.3A)
NAP  A 301 (-3.5A)
NAP  A 301 (-3.0A)
NAP  A 301 (-3.8A)
NAP  A 301 ( 3.7A)
 0.72A 2br4C-5t2uA:
5.4		 2br4C-5t2uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 205
ALA A 136
TYR A 147
PHE A 192
 None
None
NAP  A 301 (-4.4A)
None
 1.16A 2hzqA-5t2uA:
undetectable		 2hzqA-5t2uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A 234
TYR A 232
PRO A 177
THR A 133
 None
None
NAP  A 301 (-4.0A)
None
 1.49A 2q6kA-5t2uA:
undetectable		 2q6kA-5t2uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLN A 188
THR A 184
THR A 134
LEU A 102
 None
NAP  A 301 (-3.0A)
NAP  A 301 (-4.2A)
None
 1.35A 2zj0A-5t2uA:
8.3		 2zj0A-5t2uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLN A 188
THR A 184
THR A 134
LEU A 102
 None
NAP  A 301 (-3.0A)
NAP  A 301 (-4.2A)
None
 1.33A 3ce6C-5t2uA:
8.5		 3ce6C-5t2uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A 155
HIS A 138
THR A 230
 None
 0.56A 3hkuA-5t2uA:
undetectable		 3hkuA-5t2uA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 113
ASN A 131
VAL A  76
ALA A 117
ILE A  78
 None
 1.19A 4x1kD-5t2uA:
6.7		 4x1kD-5t2uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A   3
ALA A   8
LEU A   6
VAL A  80
 None
 1.08A 5a6iA-5t2uA:
undetectable		 5a6iA-5t2uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  16
GLY A  18
ALA A 212
ALA A 207
ALA A  83
 NAP  A 301 (-3.4A)
None
None
None
NAP  A 301 ( 3.7A)
 1.05A 5bw4B-5t2uA:
5.5		 5bw4B-5t2uA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  76
ASP A  75
THR A 227
ARG A 124
GLY A 125
 None
 1.50A 5m50B-5t2uA:
6.3		 5m50B-5t2uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 141
PRO A 142
GLY A 143
THR A 144
 None
 0.64A 5x24A-5t2uA:
undetectable		 5x24A-5t2uA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A 181
THR A 182
PRO A 183
ILE A  17
 None
NAP  A 301 (-2.7A)
NAP  A 301 ( 4.9A)
NAP  A 301 (-4.1A)
 1.13A 6a4iA-5t2uA:
undetectable		 6a4iA-5t2uA:
21.72