SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		5 / 10 ALA A 204
ARG A 205
LEU A 201
LEU A 174
LEU A 270
 None
 1.05A 2bxqA-5t2xA:
undetectable		 2bxqA-5t2xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 7 TYR A 221
SER A 213
ALA A 216
THR A 170
 None
 1.03A 2i91A-5t2xA:
undetectable		 2i91A-5t2xA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 7 TYR A 221
SER A 213
ALA A 216
THR A 170
 None
 1.03A 2i91B-5t2xA:
3.6		 2i91B-5t2xA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		5 / 7 GLY A 229
PHE A  76
PHE A 222
GLY A 223
PHE A  81
 None
 1.46A 3ko0M-5t2xA:
undetectable
3ko0P-5t2xA:
undetectable		 3ko0M-5t2xA:
15.36
3ko0P-5t2xA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 6 PHE A  83
ASN A 218
PHE A 222
ALA A 220
 None
 1.10A 3t3sB-5t2xA:
undetectable		 3t3sB-5t2xA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 8 PHE A  83
ASN A 218
PHE A 222
ALA A 220
 None
 1.12A 3t3sE-5t2xA:
undetectable		 3t3sE-5t2xA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 7 HIS A 168
TYR A  86
LEU A  94
PHE A  81
 None
 1.24A 4awuA-5t2xA:
undetectable		 4awuA-5t2xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		4 / 6 ILE A  98
TYR A 133
PHE A  81
ASN A  77
 None
 1.40A 4o7gB-5t2xA:
undetectable		 4o7gB-5t2xA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		3 / 3 ASP A 238
LYS A 235
LEU A 226
 None
 0.99A 4ptjA-5t2xA:
undetectable		 4ptjA-5t2xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		3 / 3 GLU A 196
ALA A 197
PHE A 176
 None
 0.61A 4v1fA-5t2xA:
undetectable		 4v1fA-5t2xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		3 / 3 GLU A 196
ALA A 197
PHE A 176
 None
 0.63A 4v1fC-5t2xA:
undetectable		 4v1fC-5t2xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5t2x UNCHARACTERIZED
PROTEIN LPG1670
(Legionella
pneumophila) 		3 / 3 TRP A 237
ILE A 217
SER A 213
 None
 0.86A 5gqbA-5t2xA:
undetectable		 5gqbA-5t2xA:
19.46