SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		4 / 4 THR G 455
LEU G 454
LEU G 342
GLN G 339
 None
 1.09A 1fbmA-5t33G:
undetectable		 1fbmA-5t33G:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5t33 CAP257-RH1 HEAVY
CHAIN
RHPA GP120 CORE
(Homo
sapiens;
Human
immunodeficiency
virus) 		5 / 12 ALA H  33
ASP H 100
GLY H  97
GLY H  98
ASN G 280
 None
 1.13A 2c49A-5t33H:
undetectable		 2c49A-5t33H:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 5t33 CAP257-RH1 HEAVY
CHAIN
RHPA GP120 CORE
(Homo
sapiens;
Human
immunodeficiency
virus) 		5 / 12 ALA H  33
GLY H  97
GLY H  98
ASN G 280
GLY G 458
 None
 0.93A 2pkmA-5t33H:
undetectable		 2pkmA-5t33H:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5t33 CAP257-RH1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 GLY H 174
PHE H 146
SER H 115
ASP H  85
LEU H 170
 None
 1.23A 3iv6D-5t33H:
undetectable		 3iv6D-5t33H:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		4 / 8 TYR G 484
ARG G 273
VAL G 270
GLY G 451
 None
 0.80A 4eq4B-5t33G:
undetectable		 4eq4B-5t33G:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		4 / 6 ASP G  57
PRO G 214
HIS G 216
ARG G 252
 None
None
None
NAG  G1448 (-3.2A)
 0.96A 4lajA-5t33G:
44.7
4lajB-5t33G:
44.9		 4lajA-5t33G:
85.56
4lajB-5t33G:
85.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		5 / 11 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 1.07A 4p66A-5t33G:
undetectable		 4p66A-5t33G:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		5 / 9 PHE G 391
ASN G 283
ILE G 284
GLY G 471
THR G 257
 None
 1.19A 4r20B-5t33G:
undetectable		 4r20B-5t33G:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		5 / 12 LEU G 342
LEU G 452
LEU G 390
VAL G 292
ILE G 333
 None
 0.85A 4x1yD-5t33G:
undetectable		 4x1yD-5t33G:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5t33 CAP257-RH1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 PHE H  67
LEU H  18
VAL H 109
GLY H   9
THR H 107
 None
 1.34A 5cp4A-5t33H:
undetectable		 5cp4A-5t33H:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		4 / 4 PHE G 468
ILE G 359
GLN G 352
ARG G 456
 None
 1.20A 5jm4B-5t33G:
undetectable		 5jm4B-5t33G:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5t33 RHPA GP120 CORE
(Human
immunodeficiency
virus) 		5 / 9 SER G 481
THR G 450
GLY G 451
LEU G 261
SER G 256
 None
None
None
NAG  G1262 (-4.3A)
None
 1.31A 5vw4A-5t33G:
undetectable		 5vw4A-5t33G:
21.71