SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		3 / 3 TRP A 159
VAL A 173
TRP A 194
 None
 1.27A 1c4dA-5t38A:
undetectable
1c4dB-5t38A:
undetectable		 1c4dA-5t38A:
5.50
1c4dB-5t38A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 8 GLU A   5
ARG A   8
ARG A   9
GLU A  98
 None
 1.06A 1cmaA-5t38A:
undetectable
1cmaB-5t38A:
undetectable		 1cmaA-5t38A:
18.82
1cmaB-5t38A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 8 SER A 149
ALA A 125
PHE A  52
ILE A  58
 None
 1.16A 1gm7A-5t38A:
undetectable
1gm7B-5t38A:
undetectable		 1gm7A-5t38A:
22.03
1gm7B-5t38A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 8 GLU A  60
GLY A  62
GLU A  84
ASP A 111
 None
SAH  A 301 (-3.4A)
SAH  A 301 (-1.8A)
SAH  A 301 (-2.9A)
 0.76A 1jg4A-5t38A:
9.5		 1jg4A-5t38A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 6 LEU A 204
PHE A 201
ALA A 202
LEU A 142
 None
 0.94A 1ukbA-5t38A:
undetectable		 1ukbA-5t38A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		5 / 12 ILE A 152
LEU A  61
ALA A 150
SER A 149
ASP A  68
 None
None
None
None
SAH  A 301 ( 4.8A)
 1.43A 2iyfB-5t38A:
3.3		 2iyfB-5t38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		5 / 12 LEU A 188
GLU A  60
GLY A  85
ASP A 111
ALA A 129
 SAH  A 301 ( 4.1A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.5A)
 0.84A 3ou6C-5t38A:
14.4		 3ou6C-5t38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 5 LEU A 120
GLY A 121
PHE A 123
ARG A 108
 None
 0.95A 3smtA-5t38A:
undetectable		 3smtA-5t38A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		5 / 9 LEU A 141
LEU A 131
ILE A  58
GLU A  60
GLU A  84
 None
SAH  A 301 (-4.3A)
None
None
SAH  A 301 (-1.8A)
 1.42A 3tmzA-5t38A:
undetectable		 3tmzA-5t38A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 7 ASP A  68
GLY A  82
ILE A  80
PHE A  48
 SAH  A 301 ( 4.8A)
None
None
None
 0.92A 4acaC-5t38A:
2.5		 4acaC-5t38A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		4 / 8 GLY A  82
LEU A  81
ILE A  80
THR A  69
 None
 0.84A 4em2A-5t38A:
undetectable		 4em2A-5t38A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		5 / 12 THR A  78
SER A  79
GLY A  54
PHE A  48
GLY A 151
 None
 1.42A 4uinH-5t38A:
undetectable
4uinL-5t38A:
undetectable		 4uinH-5t38A:
21.69
4uinL-5t38A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5t38 EVDMO1
(Micromonospora
carbonacea) 		5 / 12 ILE A  80
SER A  79
ARG A 108
GLU A 106
THR A  69
 None
 1.16A 4xt8A-5t38A:
undetectable		 4xt8A-5t38A:
23.24