SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5t3a INTEGRASE
(Visna-maedi
virus) 		3 / 3 LEU A 167
SER A 176
ASN A 172
 MES  A 304 ( 4.4A)
ACT  A 301 (-3.0A)
ACT  A 301 (-4.0A)
 0.74A 1bx4A-5t3aA:
undetectable		 1bx4A-5t3aA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 7 LEU A 115
THR A  81
VAL A 153
ASP A  66
 None
 0.94A 2zaxA-5t3aA:
undetectable		 2zaxA-5t3aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 7 LEU A 115
THR A  81
VAL A 153
ASP A  66
 None
 0.93A 3fwgB-5t3aA:
undetectable		 3fwgB-5t3aA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 7 PRO A 144
ILE A 143
GLN A 116
VAL A 153
 None
 0.98A 4a3uB-5t3aA:
undetectable		 4a3uB-5t3aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5t3a INTEGRASE
(Visna-maedi
virus) 		5 / 11 ILE A 200
SER A  83
GLY A  84
ARG A 189
GLU A  80
 None
 1.45A 4xt7A-5t3aA:
undetectable		 4xt7A-5t3aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5t3a INTEGRASE
(Visna-maedi
virus) 		5 / 12 ASP A 118
HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.30A 4yhaA-5t3aA:
undetectable		 4yhaA-5t3aA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 6 HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.23A 5ogjA-5t3aA:
undetectable		 5ogjA-5t3aA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 6 HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.23A 5ogjB-5t3aA:
undetectable		 5ogjB-5t3aA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 6 HIS A 139
VAL A  65
THR A 103
TRP A  78
 None
 1.22A 5ohhB-5t3aA:
undetectable		 5ohhB-5t3aA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5t3a INTEGRASE
(Visna-maedi
virus) 		4 / 8 TRP A 106
THR A 103
ILE A 137
PRO A 112
 None
 1.08A 6a4iA-5t3aA:
undetectable		 6a4iA-5t3aA:
20.40