SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		5 / 12 ALA A 383
TYR A 341
GLU A 367
ARG A 108
ASP A 421
 EDO  A 505 (-3.4A)
EDO  A 505 ( 3.7A)
EDO  A 505 ( 4.9A)
None
None
 1.38A 1dy4A-5t3bA:
undetectable		 1dy4A-5t3bA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 7 PHE A 263
ARG A 241
ASN A 322
GLU A 279
 None
None
EDO  A 510 (-4.6A)
EDO  A 510 ( 4.0A)
 1.28A 1t9wA-5t3bA:
undetectable		 1t9wA-5t3bA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 6 THR A 401
PHE A 368
PHE A 139
ASN A 447
 None
 1.25A 1tt0A-5t3bA:
undetectable		 1tt0A-5t3bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 6 THR A 401
PHE A 368
PHE A 139
ASN A 447
 None
 1.24A 1tt0B-5t3bA:
undetectable		 1tt0B-5t3bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 6 THR A 401
PHE A 368
PHE A 139
ASN A 447
 None
 1.24A 1tt0C-5t3bA:
0.7		 1tt0C-5t3bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 6 THR A 401
PHE A 368
PHE A 139
ASN A 447
 None
 1.26A 1tt0D-5t3bA:
undetectable		 1tt0D-5t3bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 8 TYR A  57
TYR A 397
TYR A  99
GLY A 412
 None
 1.01A 2ha4A-5t3bA:
undetectable		 2ha4A-5t3bA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 7 TYR A  57
TYR A 397
TYR A  99
GLY A 412
 None
 0.98A 2ha4B-5t3bA:
undetectable		 2ha4B-5t3bA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 4 ASP A 352
GLY A 349
LYS A 348
GLU A 347
 None
 1.48A 3hznD-5t3bA:
undetectable		 3hznD-5t3bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		5 / 9 LEU A 242
PHE A 284
ILE A 287
GLY A 195
LYS A 193
 None
 1.17A 3oshA-5t3bA:
undetectable		 3oshA-5t3bA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 7 PHE A 457
ILE A 446
VAL A 450
TYR A 100
 None
 1.11A 3p6hA-5t3bA:
undetectable		 3p6hA-5t3bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 5 LEU A 404
GLY A 412
ILE A 336
VAL A 335
 None
 0.84A 3wriB-5t3bA:
undetectable		 3wriB-5t3bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 5 LEU A 404
GLY A 412
ILE A 336
VAL A 335
 None
 0.76A 3wrkA-5t3bA:
undetectable		 3wrkA-5t3bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 TYR A 451
HIS A 140
ARG A 102
 None
 0.93A 4htfA-5t3bA:
undetectable		 4htfA-5t3bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 ARG A  88
TRP A  90
ILE A 454
 None
 0.85A 4mwxA-5t3bA:
undetectable		 4mwxA-5t3bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		5 / 11 LEU A 192
VAL A 197
LEU A 174
CYH A 288
LEU A 242
 None
 1.06A 4p65B-5t3bA:
undetectable
4p65D-5t3bA:
undetectable
4p65G-5t3bA:
undetectable
4p65H-5t3bA:
undetectable		 4p65B-5t3bA:
4.79
4p65D-5t3bA:
4.79
4p65G-5t3bA:
4.26
4p65H-5t3bA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 5 ILE A 454
VAL A 450
PHE A 415
CYH A 410
 None
 1.35A 4rzvA-5t3bA:
undetectable		 4rzvA-5t3bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 ARG A 245
ASP A 244
ARG A 241
 None
 0.62A 4wq4B-5t3bA:
undetectable		 4wq4B-5t3bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 ASP A 254
LEU A 196
GLY A 195
 None
 0.49A 4xmfA-5t3bA:
undetectable		 4xmfA-5t3bA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		4 / 5 VAL A 154
ASP A 151
PHE A 107
GLY A 146
 None
 1.25A 4xp6A-5t3bA:
undetectable		 4xp6A-5t3bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 TYR A 369
LYS A 417
LYS A 426
 EDO  A 505 (-4.6A)
None
EDO  A 505 ( 4.1A)
 1.31A 5dbyA-5t3bA:
undetectable		 5dbyA-5t3bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5t3b GLYCOSIDE HYDROLASE
(Bacteroides
plebeius) 		3 / 3 TRP A 448
ILE A 446
ASP A 445
 None
 0.55A 6i0y7-5t3bA:
undetectable		 6i0y7-5t3bA:
3.33