SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 ALA A 858
LEU A 861
ARG A1177
MET A1185
ILE A1176
 None
 0.99A 1crbA-5t3eA:
undetectable		 1crbA-5t3eA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 GLY A1132
GLN A 913
ILE A1130
VAL A1131
 None
 1.05A 1rxcC-5t3eA:
undetectable		 1rxcC-5t3eA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 11 LEU A1236
LEU A1199
SER A1091
LEU A1115
VAL A1117
 None
 1.25A 2po5B-5t3eA:
undetectable		 2po5B-5t3eA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A1236
LEU A1199
SER A1091
LEU A1115
VAL A1117
 None
 1.32A 2qd4A-5t3eA:
undetectable		 2qd4A-5t3eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 TYR A1017
ASP A1022
HIS A1169
 None
 0.84A 3e23A-5t3eA:
undetectable		 3e23A-5t3eA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 ARG A 945
GLU A1244
ASP A1248
 None
 0.82A 3g2oA-5t3eA:
undetectable		 3g2oA-5t3eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 ARG A1109
GLU A1100
ASP A1271
 None
 0.81A 3g2oA-5t3eA:
undetectable		 3g2oA-5t3eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 MET A1198
GLY A1203
LEU A 991
ILE A1230
PHE A1205
 None
 1.32A 3mneA-5t3eA:
undetectable		 3mneA-5t3eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A1225
ILE A1193
ALA A1047
ILE A1059
LEU A1052
 None
 0.99A 3vrmA-5t3eA:
undetectable		 3vrmA-5t3eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A1225
ILE A1193
PRO A1056
ILE A1059
LEU A1052
 None
 0.99A 3vrmA-5t3eA:
undetectable		 3vrmA-5t3eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		5 / 11 LEU A1094
ALA A1083
VAL A1154
GLY A1270
VAL A1097
 None
 0.93A 4dqeA-5t3eA:
undetectable		 4dqeA-5t3eA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 ARG A 947
GLU A 925
ARG A 978
 None
 0.91A 4mwvA-5t3eA:
undetectable		 4mwvA-5t3eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 PHE A 867
SER A 870
ALA A 858
LEU A 861
 None
 1.09A 4xk8A-5t3eA:
undetectable		 4xk8A-5t3eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.28A 5a06A-5t3eA:
undetectable		 5a06A-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.25A 5a06C-5t3eA:
undetectable		 5a06C-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.27A 5a06D-5t3eA:
undetectable		 5a06D-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.27A 5a06E-5t3eA:
undetectable		 5a06E-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ARG A1168
PHE A1014
ASP A1133
TYR A1121
 None
 1.28A 5a06F-5t3eA:
undetectable		 5a06F-5t3eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		4 / 6 PHE A 953
SER A 873
LEU A 982
LEU A 983
 None
 1.35A 5dzke-5t3eA:
undetectable
5dzks-5t3eA:
undetectable		 5dzke-5t3eA:
21.71
5dzks-5t3eA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 MET A1018
ASP A1133
ARG A1168
 None
 0.96A 5z6kA-5t3eA:
undetectable		 5z6kA-5t3eA:
14.09