SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		4 / 6 SER A 254
THR A 204
LEU A 260
ASP A 259
 None
 1.13A 1mxdA-5t3jA:
undetectable		 1mxdA-5t3jA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		4 / 8 SER A 254
THR A 204
LEU A 260
ASP A 259
 None
 1.11A 1mxgA-5t3jA:
undetectable		 1mxgA-5t3jA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		5 / 10 GLY A 283
THR A 286
VAL A 284
GLU A 279
SER A 254
 None
 1.32A 1z35A-5t3jA:
undetectable		 1z35A-5t3jA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		3 / 3 SER A 323
ASP A 209
CYH A 207
 None
 1.16A 2br4E-5t3jA:
undetectable		 2br4E-5t3jA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		4 / 6 LEU A 260
GLY A 312
LEU A 210
SER A 211
 None
 0.91A 3aiaA-5t3jA:
undetectable		 3aiaA-5t3jA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		6 / 12 ILE A 165
GLY A 176
ILE A 178
ILE A 278
ALA A 166
LEU A 272
 None
 1.41A 3fpjA-5t3jA:
undetectable		 3fpjA-5t3jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		5 / 9 ALA A  74
ILE A 178
GLY A 162
ILE A 148
ILE A 165
 None
 1.11A 3ndwB-5t3jA:
undetectable		 3ndwB-5t3jA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		4 / 4 ALA A 310
VAL A 258
GLY A 256
THR A 204
 None
 1.15A 4ubeA-5t3jA:
undetectable		 4ubeA-5t3jA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		4 / 8 ASP A 270
ASP A 149
ASP A 146
ILE A  81
 None
 1.07A 5cfsA-5t3jA:
undetectable		 5cfsA-5t3jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		5 / 10 LEU A 160
CYH A 245
GLY A 244
TYR A 243
VAL A 261
 None
 1.50A 5tqrB-5t3jA:
undetectable		 5tqrB-5t3jA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5t3j INOSITOL
MONOPHOSPHATASE
(Medicago
truncatula) 		3 / 3 SER A 281
SER A 254
ALA A 273
 None
 0.65A 6dwnC-5t3jA:
undetectable		 6dwnC-5t3jA:
19.03