SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 7 VAL A 269
LEU A 283
THR A 285
LEU A 286
 None
 0.95A 1jgsA-5t3oA:
undetectable		 1jgsA-5t3oA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 7 PHE A  93
ALA A 114
PHE A 139
PHE A 138
 None
 1.15A 1lqtA-5t3oA:
2.3		 1lqtA-5t3oA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 7 PHE A  93
ALA A 114
PHE A 139
PHE A 138
 None
 1.15A 1lquA-5t3oA:
undetectable		 1lquA-5t3oA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		5 / 12 PRO A 265
GLY A 213
ILE A 218
LEU A 229
VAL A 230
 None
 1.19A 1r30A-5t3oA:
3.2		 1r30A-5t3oA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		5 / 12 PRO A 265
GLY A 213
ILE A 218
LEU A 229
VAL A 230
 None
 1.19A 1r30B-5t3oA:
undetectable		 1r30B-5t3oA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 6 LEU A  49
ILE A  56
VAL A  86
ALA A  78
 None
 1.08A 2j5mA-5t3oA:
undetectable		 2j5mA-5t3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.21A 2obvA-5t3oA:
undetectable		 2obvA-5t3oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.16A 2p02A-5t3oA:
undetectable		 2p02A-5t3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		3 / 3 LYS A  79
ARG A  85
VAL A  54
 None
 1.00A 2r2vC-5t3oA:
undetectable
2r2vD-5t3oA:
undetectable		 2r2vC-5t3oA:
8.64
2r2vD-5t3oA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		5 / 12 ALA A  83
GLY A 121
GLY A  80
LEU A  72
ALA A 122
 None
 0.89A 3douA-5t3oA:
3.6		 3douA-5t3oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 6 PHE A  93
ILE A 113
ALA A 114
ALA A 122
 None
 0.95A 3mdrB-5t3oA:
undetectable		 3mdrB-5t3oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 5 ASP A 171
ASP A 220
ASP A 221
ARG A  97
 ADP  A 401 (-3.4A)
None
None
ADP  A 401 (-3.4A)
 1.15A 3naiA-5t3oA:
undetectable		 3naiA-5t3oA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 5 VAL A 305
LEU A 308
SER A 306
MET A 128
 None
 1.38A 4e1gA-5t3oA:
undetectable		 4e1gA-5t3oA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		5 / 12 PHE A  93
LEU A  68
ILE A 113
ALA A 114
ALA A 122
 None
 0.86A 4enhA-5t3oA:
undetectable		 4enhA-5t3oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 ARG A 301
ASP A  53
LEU A   5
ILE A   7
 None
 1.00A 4k0bA-5t3oA:
undetectable		 4k0bA-5t3oA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.18A 4kttA-5t3oA:
undetectable		 4kttA-5t3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.23A 4kttC-5t3oA:
undetectable		 4kttC-5t3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.16A 4ndnA-5t3oA:
undetectable		 4ndnA-5t3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.18A 5a1iA-5t3oA:
undetectable		 5a1iA-5t3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.23A 5t8sB-5t3oA:
undetectable		 5t8sB-5t3oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 6 GLN A 134
VAL A 135
ALA A 110
THR A 109
 None
 1.06A 6cduB-5t3oA:
undetectable
6cduC-5t3oA:
undetectable		 6cduB-5t3oA:
21.99
6cduC-5t3oA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 5 THR A 129
ARG A 177
GLN A 134
ASP A 102
 None
None
None
ADP  A 401 (-3.1A)
 1.21A 6ecxA-5t3oA:
3.6		 6ecxA-5t3oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.17A 6fboA-5t3oA:
undetectable		 6fboA-5t3oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5t3o RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermus
thermophilus) 		4 / 8 HIS A 131
ASP A 221
SER A 224
ASP A 171
 ADP  A 401 (-3.7A)
None
SO4  A 403 (-4.5A)
ADP  A 401 (-3.4A)
 1.19A 6fcdA-5t3oA:
undetectable		 6fcdA-5t3oA:
16.18