SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	5t3s	FAB 35022 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 163 VAL D 182 SER D 180 ASN D 197 ASN D 155	None	1.45A	2y03A-5t3sD: undetectable	2y03A-5t3sD: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NYA_A_JTZA1203_1 (BETA-2 ADRENERGIC RECEPTOR, LYSOZYME)	5t3s	FAB 35022 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 163 VAL D 182 SER D 180 ASN D 197 ASN D 155	None	1.40A	3nyaA-5t3sD: undetectable	3nyaA-5t3sD: 18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB0_A_ACTA401_0 (UNCHARACTERIZED PROTEIN)	5t3s	FAB 35022 HEAVY CHAIN (Homo sapiens)	5 / 9	SER D 130 GLY D 133 SER D 132 GLY D 134 THR D 135	None	1.42A	4lb0A-5t3sD: undetectable	4lb0A-5t3sD: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	5t3s	FAB 35022 HEAVY CHAIN (Homo sapiens)	4 / 7	VAL D 18 ARG D 38 TYR D 90 LEU D 59	None	0.92A	5umwB-5t3sD: undetectable 5umwE-5t3sD: undetectable	5umwB-5t3sD: 15.16 5umwE-5t3sD: 15.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","5t3s","FAB 35022 HEAVY CHAIN","Homo sapiens",5,"VAL D 163;VAL D 182;SER D 180;ASN D 197;ASN D 155","None","1.45A","2y03A-5t3sD:undetectable","2y03A-5t3sD:20.68"],["3NYA_A_JTZA1203_1","BETA-2 ADRENERGIC RECEPTOR, LYSOZYME","5t3s","FAB 35022 HEAVY CHAIN","Homo sapiens",5,"VAL D 163;VAL D 182;SER D 180;ASN D 197;ASN D 155","None","1.40A","3nyaA-5t3sD:undetectable","3nyaA-5t3sD:18.14"],["4LB0_A_ACTA401_0","UNCHARACTERIZED PROTEIN","5t3s","FAB 35022 HEAVY CHAIN","Homo sapiens",5,"SER D 130;GLY D 133;SER D 132;GLY D 134;THR D 135","None","1.42A","4lb0A-5t3sD:undetectable","4lb0A-5t3sD:22.48"],["5UMW_B_RBFB201_1","GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE;GLYOXALASE\/BLEOMYCIN RESISANCE PROTEIN\/DIOXYGENASE","5t3s","FAB 35022 HEAVY CHAIN","Homo sapiens",4,"VAL D  18;ARG D  38;TYR D  90;LEU D  59","None","0.92A","5umwB-5t3sD:undetectable;5umwE-5t3sD:undetectable","5umwB-5t3sD:15.16;5umwE-5t3sD:15.16"]]