SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		5 / 9 LEU A  63
VAL A  59
ASP A  95
ILE A  96
VAL A  71
 None
 1.43A 2l8mA-5t3uA:
undetectable		 2l8mA-5t3uA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.12A 2nsiA-5t3uA:
undetectable
2nsiB-5t3uA:
undetectable		 2nsiA-5t3uA:
17.52
2nsiB-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.13A 2nsiA-5t3uA:
undetectable
2nsiB-5t3uA:
undetectable		 2nsiA-5t3uA:
17.52
2nsiB-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.14A 2nsiC-5t3uA:
undetectable
2nsiD-5t3uA:
undetectable		 2nsiC-5t3uA:
17.52
2nsiD-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.13A 2nsiC-5t3uA:
undetectable
2nsiD-5t3uA:
undetectable		 2nsiC-5t3uA:
17.52
2nsiD-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.11A 3e7gA-5t3uA:
undetectable
3e7gB-5t3uA:
undetectable		 3e7gA-5t3uA:
16.98
3e7gB-5t3uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.13A 3e7gA-5t3uA:
undetectable
3e7gB-5t3uA:
undetectable		 3e7gA-5t3uA:
16.98
3e7gB-5t3uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.19A 3e7gC-5t3uA:
undetectable
3e7gD-5t3uA:
undetectable		 3e7gC-5t3uA:
16.98
3e7gD-5t3uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 8 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.05A 3e7gC-5t3uA:
undetectable
3e7gD-5t3uA:
undetectable		 3e7gC-5t3uA:
16.98
3e7gD-5t3uA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 5 ASN A  66
ASP A  60
GLU A  52
SER A  65
 None
 1.41A 3p2kC-5t3uA:
undetectable		 3p2kC-5t3uA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 8 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.26A 4cx7A-5t3uA:
undetectable
4cx7B-5t3uA:
undetectable		 4cx7A-5t3uA:
17.52
4cx7B-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 8 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.29A 4cx7A-5t3uA:
undetectable
4cx7B-5t3uA:
undetectable		 4cx7A-5t3uA:
17.52
4cx7B-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 8 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.21A 4cx7C-5t3uA:
undetectable
4cx7D-5t3uA:
undetectable		 4cx7C-5t3uA:
17.52
4cx7D-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.23A 4cx7C-5t3uA:
undetectable
4cx7D-5t3uA:
undetectable		 4cx7C-5t3uA:
17.52
4cx7D-5t3uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 SER A 111
ARG A   7
GLU A 120
ILE A 121
 None
 1.02A 4d33B-5t3uA:
undetectable		 4d33B-5t3uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 8 SER A 111
ARG A   7
GLU A 120
ILE A 121
 None
 0.94A 4d39A-5t3uA:
undetectable		 4d39A-5t3uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 SER A 111
ARG A   7
GLU A 120
ILE A 121
 None
 1.00A 4d39B-5t3uA:
undetectable		 4d39B-5t3uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 PHE A  28
GLU A  26
MET A  23
ILE A 102
 None
 1.29A 4nosA-5t3uA:
undetectable
4nosB-5t3uA:
undetectable		 4nosA-5t3uA:
16.94
4nosB-5t3uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5t3u PTS SYSTEM, IIA
COMPONENT
(Streptococcus
pneumoniae) 		4 / 7 MET A  23
ILE A 102
PHE A  28
GLU A  26
 None
 1.25A 4nosC-5t3uA:
undetectable
4nosD-5t3uA:
undetectable		 4nosC-5t3uA:
16.94
4nosD-5t3uA:
16.94