SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 5 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.10A 1mz9D-5t47A:
undetectable		 1mz9D-5t47A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 0.93A 1mz9E-5t47A:
undetectable		 1mz9E-5t47A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 6 PRO A 114
HIS A 111
ASP A 104
TYR A 109
 None
 1.26A 2lh8A-5t47A:
undetectable		 2lh8A-5t47A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4G, ISOFORM A
(Drosophila
melanogaster) 		5 / 11 LEU B 626
LEU B 629
GLU A 103
LEU A  72
LEU A 163
 None
 1.33A 3hm1B-5t47B:
undetectable		 3hm1B-5t47B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4G, ISOFORM A
(Drosophila
melanogaster) 		5 / 10 LEU B 626
LEU B 629
GLU A 103
LEU A  72
LEU A 163
 None
 1.45A 3ollA-5t47B:
undetectable		 3ollA-5t47B:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		3 / 3 ASN A  74
TRP A  76
ASP A 178
 None
 1.22A 4a7tA-5t47A:
undetectable
4a7tF-5t47A:
undetectable		 4a7tA-5t47A:
22.16
4a7tF-5t47A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 8 ILE A 148
ILE A 194
ALA A 183
TRP A 146
 None
 0.97A 4ou1A-5t47A:
undetectable		 4ou1A-5t47A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 4 ASN A 192
ILE A 112
TYR A  80
PHE A 127
 None
 1.27A 5igvA-5t47A:
undetectable		 5igvA-5t47A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
(Drosophila
melanogaster) 		4 / 7 LEU A 126
LYS A 128
LEU A 169
GLU A 172
 None
 1.02A 5t7bA-5t47A:
undetectable		 5t7bA-5t47A:
11.44