SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		4 / 8 ILE A 364
PHE A 340
LEU A 328
VAL A 332
 None
 0.90A 1fslB-5t4mA:
undetectable		 1fslB-5t4mA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		4 / 6 ASP A 341
LEU A 342
VAL A 343
ILE A 344
 None
 0.93A 1s9qA-5t4mA:
undetectable		 1s9qA-5t4mA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		5 / 11 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.44A 2iyfA-5t4mA:
undetectable		 2iyfA-5t4mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		5 / 12 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.44A 2iyfB-5t4mA:
undetectable		 2iyfB-5t4mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		4 / 4 GLN A 446
PRO A 447
VAL A 448
GLU A 385
 None
None
None
CA  A 704 ( 2.8A)
 1.00A 3huoA-5t4mA:
undetectable		 3huoA-5t4mA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		3 / 3 PRO A 314
ASP A 312
GLU A 311
 None
 0.66A 3v4tC-5t4mA:
undetectable		 3v4tC-5t4mA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		4 / 8 PHE A 316
HIS A 337
GLU A 267
ARG A 315
 None
 1.15A 4cx7A-5t4mA:
undetectable
4cx7B-5t4mA:
undetectable		 4cx7A-5t4mA:
21.68
4cx7B-5t4mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		5 / 11 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.46A 4m83A-5t4mA:
undetectable		 4m83A-5t4mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		5 / 11 VAL A 513
TYR A 525
ASN A 482
ALA A 564
SER A 576
 None
None
CA  A 705 (-3.0A)
None
None
 1.41A 4m83B-5t4mA:
undetectable		 4m83B-5t4mA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5t4m PROTOCADHERIN-15
(Homo
sapiens) 		3 / 3 ASP A 516
ASP A 514
ASN A 575
 CA  A 704 ( 3.3A)
CA  A 705 (-2.1A)
None
 0.84A 4q5mA-5t4mA:
undetectable		 4q5mA-5t4mA:
21.59