SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA D 392
VAL D 390
TRP D 295
 None
 0.86A 1micA-5t4yD:
undetectable
1micB-5t4yD:
undetectable		 1micA-5t4yD:
2.14
1micB-5t4yD:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.00A 1p6kA-5t4yD:
undetectable		 1p6kA-5t4yD:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.05A 1p6kB-5t4yD:
undetectable		 1p6kB-5t4yD:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.08A 1rs6A-5t4yD:
undetectable		 1rs6A-5t4yD:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP D 450
GLU D 514
ARG D 513
LYS D 485
 None
 1.38A 1yc2A-5t4yD:
undetectable
1yc2B-5t4yD:
undetectable
1yc2E-5t4yD:
undetectable		 1yc2A-5t4yD:
13.65
1yc2B-5t4yD:
13.65
1yc2E-5t4yD:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.02A 1zzqA-5t4yD:
undetectable		 1zzqA-5t4yD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.10A 1zzqB-5t4yD:
undetectable		 1zzqB-5t4yD:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.04A 1zzuB-5t4yD:
undetectable		 1zzuB-5t4yD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR D 771
GLY D 946
PHE D 948
SER D 947
 None
 1.20A 2a3cA-5t4yD:
undetectable		 2a3cA-5t4yD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR D 771
GLY D 946
PHE D 948
SER D 947
 None
 1.22A 2a3cB-5t4yD:
undetectable		 2a3cB-5t4yD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 9 ILE D 844
GLY D 827
PHE D 813
HIS D 822
ARG D 834
 None
 1.20A 2y7wA-5t4yD:
undetectable		 2y7wA-5t4yD:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D1001
ALA D 381
THR D 300
ILE D 334
 None
 0.83A 3bpxA-5t4yD:
undetectable
3bpxB-5t4yD:
undetectable		 3bpxA-5t4yD:
9.66
3bpxB-5t4yD:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE D 592
TYR D 589
LEU D 573
 None
 0.69A 3keeB-5t4yD:
undetectable		 3keeB-5t4yD:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.08A 3n62B-5t4yD:
undetectable		 3n62B-5t4yD:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG D 937
ASP D 845
ASP D 848
ASP D 837
 None
 1.44A 3naiA-5t4yD:
undetectable		 3naiA-5t4yD:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR D 461
ASP D 532
ASP D 419
 None
 0.76A 3r24A-5t4yD:
undetectable		 3r24A-5t4yD:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP D 696
SER D 707
GLY D 706
ASP D 615
 None
 1.33A 3w9tB-5t4yD:
1.2		 3w9tB-5t4yD:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP D 696
SER D 707
GLY D 706
ASP D 615
 None
 1.33A 3w9tC-5t4yD:
0.0		 3w9tC-5t4yD:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP D 696
SER D 707
GLY D 706
ASP D 615
 None
 1.34A 3w9tD-5t4yD:
0.0		 3w9tD-5t4yD:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR D 422
THR D 368
GLU D 481
 None
 0.82A 4df3A-5t4yD:
undetectable		 4df3A-5t4yD:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR D 422
THR D 368
GLU D 481
 None
 0.81A 4df3B-5t4yD:
undetectable		 4df3B-5t4yD:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG D 577
TRP D 685
GLY D 579
 None
 1.02A 4e7cA-5t4yD:
undetectable		 4e7cA-5t4yD:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 4 SER D 581
GLY D 549
GLU D 481
 None
 0.52A 4juoA-5t4yD:
undetectable
4juoC-5t4yD:
undetectable		 4juoA-5t4yD:
19.14
4juoC-5t4yD:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 556
ASP D 578
GLU D 510
THR D 574
 None
 1.16A 4lnwA-5t4yD:
undetectable		 4lnwA-5t4yD:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE D 299
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 0.96A 4o1eA-5t4yD:
undetectable		 4o1eA-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE D1004
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 1.05A 4o1eA-5t4yD:
undetectable		 4o1eA-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE D 299
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 0.94A 4o1eB-5t4yD:
undetectable		 4o1eB-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE D1004
LEU D 414
GLY D 376
ILE D 378
ASN D 999
 None
 1.07A 4o1eB-5t4yD:
undetectable		 4o1eB-5t4yD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP D 889
LYS D 893
LEU D 905
 None
 0.91A 4ptjA-5t4yD:
undetectable		 4ptjA-5t4yD:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 PRO D 998
SER D1001
GLU D 379
ASP D 294
 None
 1.22A 4uacA-5t4yD:
undetectable		 4uacA-5t4yD:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY D 655
THR D 656
GLY D 672
ASN D 642
 None
 0.76A 5k4pA-5t4yD:
undetectable		 5k4pA-5t4yD:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 THR D 800
HIS D 799
ALA D 803
ASP D 854
 None
 0.97A 5mfxA-5t4yD:
undetectable		 5mfxA-5t4yD:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU D 250
ARG D 929
TYR D 245
 None
 0.36A 5trqB-5t4yD:
undetectable		 5trqB-5t4yD:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP D 488
MET D 487
ASN D 512
 None
 1.45A 5uc1B-5t4yD:
undetectable		 5uc1B-5t4yD:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.30A 5vuoB-5t4yD:
undetectable		 5vuoB-5t4yD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 SER D 343
ASN D 309
GLN D 307
ASN D 366
 None
 1.28A 6auuB-5t4yD:
undetectable		 6auuB-5t4yD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 5t4y SUSC HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE D 896
ILE D 833
ASN D 933
ASP D 931
 None
 1.43A 6dhbA-5t4yD:
undetectable		 6dhbA-5t4yD:
7.32