SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JW3_A_TOPA208_1 (DIHYDROFOLATE REDUCTASE)	5t50	LECTIN (Bauhinia forficata)	5 / 10	LEU A 174 VAL A 192 ILE A 84 LEU A 56 ILE A 197	None	1.13A	3jw3A-5t50A: undetectable	3jw3A-5t50A: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_4 (HIV-1 PROTEASE)	5t50	LECTIN (Bauhinia forficata)	4 / 4	ARG A 70 ASP A 120 GLY A 95 THR A 32	None CA A 302 ( 2.2A) EDO A 307 ( 3.9A) None	1.48A	3k4vB-5t50A: undetectable	3k4vB-5t50A: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_K_BO2K305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	5t50	LECTIN (Bauhinia forficata)	5 / 11	ALA A 161 THR A 162 ALA A 163 GLY A 183 GLY A 184	None	1.04A	5lf3K-5t50A: undetectable 5lf3L-5t50A: undetectable	5lf3K-5t50A: 19.92 5lf3L-5t50A: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF3_Y_BO2Y305_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-1)	5t50	LECTIN (Bauhinia forficata)	5 / 11	ALA A 161 THR A 162 ALA A 163 GLY A 183 GLY A 184	None	1.03A	5lf3Y-5t50A: undetectable 5lf3Z-5t50A: undetectable	5lf3Y-5t50A: 19.92 5lf3Z-5t50A: 23.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3JW3_A_TOPA208_1","DIHYDROFOLATE REDUCTASE","5t50","LECTIN","Bauhinia forficata",5,"LEU A 174;VAL A 192;ILE A  84;LEU A  56;ILE A 197","None","1.13A","3jw3A-5t50A:undetectable","3jw3A-5t50A:20.24"],["3K4V_B_ROCB201_4","HIV-1 PROTEASE","5t50","LECTIN","Bauhinia forficata",4,"ARG A  70;ASP A 120;GLY A  95;THR A  32","None; CA A 302 ( 2.2A);EDO A 307 ( 3.9A);None","1.48A","3k4vB-5t50A:undetectable","3k4vB-5t50A:18.33"],["5LF3_K_BO2K305_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-1","5t50","LECTIN","Bauhinia forficata",5,"ALA A 161;THR A 162;ALA A 163;GLY A 183;GLY A 184","None","1.04A","5lf3K-5t50A:undetectable;5lf3L-5t50A:undetectable","5lf3K-5t50A:19.92;5lf3L-5t50A:23.11"],["5LF3_Y_BO2Y305_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-1","5t50","LECTIN","Bauhinia forficata",5,"ALA A 161;THR A 162;ALA A 163;GLY A 183;GLY A 184","None","1.03A","5lf3Y-5t50A:undetectable;5lf3Z-5t50A:undetectable","5lf3Y-5t50A:19.92;5lf3Z-5t50A:23.11"]]