SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5t53 N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		4 / 5 TYR A 677
LYS A 681
VAL A 719
ILE A 685
 None
 0.89A 1opjA-5t53A:
undetectable		 1opjA-5t53A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5t53 N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		4 / 7 TYR A 677
LYS A 681
VAL A 719
ILE A 685
 None
 0.94A 3mssB-5t53A:
undetectable		 3mssB-5t53A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 5t53 N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		5 / 9 ARG A 786
ILE A 667
ALA A 784
LEU A 709
VAL A 774
 None
None
ACO  A 901 (-3.3A)
None
ACO  A 901 (-3.4A)
 1.49A 3o01A-5t53A:
1.5
3o01B-5t53A:
undetectable		 3o01A-5t53A:
20.25
3o01B-5t53A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5t53 N-ACETYLTRANSFERASE
ESCO1
(Homo
sapiens) 		4 / 6 TYR A 677
LYS A 681
VAL A 719
ILE A 685
 None
 0.97A 3pyyA-5t53A:
undetectable		 3pyyA-5t53A:
20.26