SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		4 / 8 TYR A  27
ILE A   5
LEU A 157
VAL A  62
 None
 0.77A 1fslB-5t57A:
undetectable		 1fslB-5t57A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A 137
GLY A 136
GLY A 135
PRO A 118
ASP A 126
 None
 0.86A 1qzzA-5t57A:
6.0		 1qzzA-5t57A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A   9
GLY A  11
VAL A  34
SER A  35
PRO A  68
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-4.4A)
NAD  A 301 ( 3.9A)
NAD  A 301 (-4.2A)
 0.91A 1sg9B-5t57A:
5.0		 1sg9B-5t57A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A 137
GLY A 136
GLY A 135
PRO A 118
ASP A 126
 None
 0.87A 1xdsA-5t57A:
5.3		 1xdsA-5t57A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A 137
GLY A 136
GLY A 135
PRO A 118
ASP A 126
 None
 0.93A 1xdsB-5t57A:
5.6		 1xdsB-5t57A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		4 / 7 GLY A   9
GLY A  11
GLU A  33
ALA A  66
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.6A)
 0.77A 3fpjB-5t57A:
6.4		 3fpjB-5t57A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 ASN A 225
GLY A 228
MET A 199
LEU A 196
ILE A 120
 None
 1.43A 3h52A-5t57A:
undetectable		 3h52A-5t57A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A   9
ALA A  10
GLY A  12
GLY A  11
LEU A  42
 NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.2A)
NAD  A 301 (-4.3A)
None
 0.84A 4o33A-5t57A:
3.2		 4o33A-5t57A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLU A 189
ILE A  75
GLY A   9
LEU A  92
HIS A 114
 CA  A 302 ( 3.8A)
NAD  A 301 (-4.2A)
NAD  A 301 (-3.4A)
NAD  A 301 (-4.1A)
ZN  A 303 ( 3.3A)
 1.14A 5esgA-5t57A:
undetectable		 5esgA-5t57A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 10 GLY A   9
GLY A  12
GLU A  33
VAL A  34
ILE A  75
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.4A)
NAD  A 301 (-4.2A)
 0.71A 6exiA-5t57A:
3.7		 6exiA-5t57A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 10 GLY A   9
GLY A  12
GLU A  33
VAL A  34
ILE A  75
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.4A)
NAD  A 301 (-4.2A)
 0.68A 6exiB-5t57A:
3.6		 6exiB-5t57A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A   9
GLY A  12
GLU A  33
VAL A  34
ILE A  75
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.4A)
NAD  A 301 (-4.2A)
 0.70A 6exiC-5t57A:
3.8
6exiD-5t57A:
3.7		 6exiC-5t57A:
14.64
6exiD-5t57A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN
(Cupriavidus
necator) 		5 / 12 GLY A   9
GLY A  12
GLU A  33
VAL A  34
ILE A  75
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.4A)
NAD  A 301 (-4.2A)
 0.71A 6exiC-5t57A:
3.7
6exiD-5t57A:
3.7		 6exiC-5t57A:
14.64
6exiD-5t57A:
14.64