SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5t58 KLLA0D15741P
KLLA0E05809P
(Kluyveromyces
lactis) 		3 / 3 ASP D 392
LEU B 118
LEU B 121
 None
 0.76A 1ikeA-5t58D:
undetectable		 1ikeA-5t58D:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5t58 KLLA0D15741P
KLLA0E05809P
(Kluyveromyces
lactis) 		3 / 3 ASP D 392
LEU B 118
LEU B 121
 None
 0.70A 1np1B-5t58D:
undetectable		 1np1B-5t58D:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5t58 KLLA0C15939P
KLLA0D15741P
KLLA0F02343P
(Kluyveromyces
lactis) 		4 / 7 TRP N 107
GLU N 108
ILE A  21
LEU D 375
 None
 1.44A 1q0yH-5t58N:
undetectable
1q0yL-5t58N:
undetectable		 1q0yH-5t58N:
22.35
1q0yL-5t58N:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5t58 KLLA0F02343P
KLLA0C15939P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		3 / 3 GLN N 123
HIS A 108
ARG N 118
 None
 0.88A 1zlqA-5t58N:
undetectable		 1zlqA-5t58N:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		4 / 8 TYR N 179
GLN D 439
ARG D 443
ILE N 182
 None
 1.00A 2xytE-5t58N:
undetectable		 2xytE-5t58N:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		4 / 8 TYR N 179
GLN D 439
ARG D 443
ILE N 182
 None
 1.06A 2xytH-5t58N:
undetectable		 2xytH-5t58N:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		4 / 8 ARG N  31
SER D 286
TYR N  88
VAL N  30
 None
 1.35A 2y05A-5t58N:
undetectable
2y05B-5t58N:
undetectable		 2y05A-5t58N:
19.76
2y05B-5t58N:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		4 / 7 ILE D 301
LEU N  55
THR D 290
ARG N  31
 None
 1.27A 3nxuA-5t58D:
undetectable		 3nxuA-5t58D:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5t58 KLLA0F02343P
KLLA0E05809P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		3 / 3 LYS B 114
ARG A 105
ASP A 116
 None
 1.43A 3o7wA-5t58B:
undetectable		 3o7wA-5t58B:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		3 / 3 THR A  39
ASN A  40
GLU A  69
 None
 0.74A 3v4tA-5t58A:
undetectable
3v4tC-5t58A:
undetectable		 3v4tA-5t58A:
20.38
3v4tC-5t58A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5t58 KLLA0F02343P
KLLA0E05809P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		5 / 12 VAL B  23
LEU B  28
SER B  31
ILE A  27
VAL A  31
 None
 1.08A 3w68A-5t58B:
undetectable		 3w68A-5t58B:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		4 / 8 GLU N  39
ILE D 366
GLN N  45
ILE N  47
 None
 0.88A 4mj8A-5t58N:
undetectable		 4mj8A-5t58N:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5t58 KLLA0C15939P
KLLA0D15741P
(Kluyveromyces
lactis) 		5 / 11 LEU D 294
VAL N  58
LEU N  55
LEU D 272
LEU N  51
 None
 1.25A 4or0B-5t58D:
undetectable		 4or0B-5t58D:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5t58 KLLA0E05809P
KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 12 TYR A  18
ILE B  86
LEU A  88
LEU A  83
LEU A  16
 None
 0.93A 5ienA-5t58A:
undetectable		 5ienA-5t58A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 12 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.47A 5iqbA-5t58A:
undetectable		 5iqbA-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 12 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.47A 5iqbD-5t58A:
2.6		 5iqbD-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 12 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.47A 5iqeC-5t58A:
undetectable		 5iqeC-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 12 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.45A 5iqeD-5t58A:
2.5		 5iqeD-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5t58 KLLA0D15741P
(Kluyveromyces
lactis) 		3 / 3 SER D 390
LYS D 391
SER D 394
 None
 0.80A 6az3P-5t58D:
undetectable		 6az3P-5t58D:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 10 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.49A 6c5uA-5t58A:
2.5		 6c5uA-5t58A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 5t58 KLLA0F02343P
(Kluyveromyces
lactis) 		5 / 10 ASN A  40
TYR A  36
GLU A  73
SER A  70
GLU A  69
 None
 1.50A 6c5uD-5t58A:
2.6		 6c5uD-5t58A:
26.71