SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A 135
LEU A 138
THR A  13
LEU A  10
THR A 164
 None
NAD  A 300 (-3.8A)
None
None
None
 1.06A 1cd2A-5t5qA:
undetectable		 1cd2A-5t5qA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  17
LEU A  39
ASP A  63
ILE A 113
SER A 140
 NAD  A 300 (-3.3A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.5A)
NAD  A 300 ( 4.1A)
NAD  A 300 ( 3.8A)
 1.06A 1zq9A-5t5qA:
6.1		 1zq9A-5t5qA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A 135
LEU A 138
THR A  13
LEU A  10
THR A 164
 None
NAD  A 300 (-3.8A)
None
None
None
 1.03A 2cd2A-5t5qA:
undetectable		 2cd2A-5t5qA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ALA A  70
ARG A 124
ASP A 116
TYR A 120
 None
 1.18A 2e5dA-5t5qA:
undetectable
2e5dB-5t5qA:
undetectable		 2e5dA-5t5qA:
18.97
2e5dB-5t5qA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ASP A 116
TYR A 120
ALA A  70
ARG A 124
 None
 1.18A 2e5dA-5t5qA:
undetectable
2e5dB-5t5qA:
undetectable		 2e5dA-5t5qA:
18.97
2e5dB-5t5qA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ALA A  62
ILE A  60
ALA A 125
ILE A  84
MET A  78
 None
 0.89A 2h42B-5t5qA:
undetectable		 2h42B-5t5qA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 LEU A 126
ALA A 125
LEU A 121
MET A 163
 None
 1.11A 2oaxA-5t5qA:
undetectable		 2oaxA-5t5qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		6 / 12 GLY A  14
GLY A  17
ASP A  40
ASP A  63
ALA A  64
ILE A 113
 NAD  A 300 ( 3.8A)
NAD  A 300 (-3.3A)
None
NAD  A 300 (-3.5A)
NAD  A 300 (-3.4A)
NAD  A 300 ( 4.1A)
 1.16A 3fuuA-5t5qA:
5.6		 3fuuA-5t5qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		6 / 11 GLY A  14
GLY A  17
ASP A  40
ASP A  63
ALA A  64
ILE A 113
 NAD  A 300 ( 3.8A)
NAD  A 300 (-3.3A)
None
NAD  A 300 (-3.5A)
NAD  A 300 (-3.4A)
NAD  A 300 ( 4.1A)
 0.86A 3grvA-5t5qA:
6.4		 3grvA-5t5qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 LEU A 126
ALA A 128
LYS A 130
LEU A  87
ARG A   8
 None
 1.31A 3gyqA-5t5qA:
2.9
3gyqB-5t5qA:
3.0		 3gyqA-5t5qA:
25.84
3gyqB-5t5qA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 11 ALA A 139
VAL A 161
ALA A 155
GLY A 154
ALA A 143
 None
 0.94A 3mg0K-5t5qA:
undetectable
3mg0L-5t5qA:
undetectable		 3mg0K-5t5qA:
20.96
3mg0L-5t5qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  14
ILE A  23
ASP A  38
LEU A  39
ASP A  63
 NAD  A 300 ( 3.8A)
None
NAD  A 300 (-2.7A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.5A)
 0.38A 3q87B-5t5qA:
6.9		 3q87B-5t5qA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		4 / 5 SER A 140
ILE A  19
TYR A 153
GLY A 183
 NAD  A 300 ( 3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-4.6A)
None
 0.95A 3uboB-5t5qA:
6.7		 3uboB-5t5qA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 ILE A  93
GLY A 117
ALA A  91
ALA A  70
ASP A  63
 None
None
NAD  A 300 ( 3.9A)
None
NAD  A 300 (-3.5A)
 1.03A 4kicB-5t5qA:
6.2		 4kicB-5t5qA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		6 / 12 GLY A  14
GLY A  17
LEU A  39
ASP A  63
ALA A  64
ILE A 113
 NAD  A 300 ( 3.8A)
NAD  A 300 (-3.3A)
NAD  A 300 (-4.0A)
NAD  A 300 (-3.5A)
NAD  A 300 (-3.4A)
NAD  A 300 ( 4.1A)
 1.28A 4krhA-5t5qA:
4.8		 4krhA-5t5qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		4 / 7 ILE A 220
ILE A 135
THR A  13
PHE A  27
 None
 0.82A 5fukA-5t5qA:
undetectable
5fukB-5t5qA:
undetectable		 5fukA-5t5qA:
27.11
5fukB-5t5qA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  14
ASP A  38
ASP A  40
ASP A  63
ALA A  64
 NAD  A 300 ( 3.8A)
NAD  A 300 (-2.7A)
None
NAD  A 300 (-3.5A)
NAD  A 300 (-3.4A)
 0.81A 6bq4A-5t5qA:
7.4		 6bq4A-5t5qA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 GLY A  14
ASP A  38
ASP A  40
ASP A  63
ALA A  64
 NAD  A 300 ( 3.8A)
NAD  A 300 (-2.7A)
None
NAD  A 300 (-3.5A)
NAD  A 300 (-3.4A)
 0.83A 6bq4B-5t5qA:
7.4		 6bq4B-5t5qA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5t5q SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
SDR:GLUCOSE/RIBITOL
DEHYDROGENASE
(Brucella
abortus) 		5 / 12 VAL A  11
THR A   9
VAL A 118
LEU A 121
GLY A  83
 None
 1.11A 6drzA-5t5qA:
undetectable		 6drzA-5t5qA:
24.29