SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		3 / 3 LYS B   6
ARG B  81
VAL B  80
 None
 0.90A 2r2vC-5t5wB:
undetectable
2r2vD-5t5wB:
undetectable		 2r2vC-5t5wB:
16.31
2r2vD-5t5wB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5t5w INTERFERON LAMBDA
RECEPTOR 1
INTERFERON LAMBDA-3
(Homo
sapiens) 		4 / 8 LYS C  21
LYS C  24
SER B  42
ASP B  98
 None
 1.34A 2rk8A-5t5wC:
3.2		 2rk8A-5t5wC:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5t5w INTERFERON LAMBDA
RECEPTOR 1
INTERFERON LAMBDA-3
(Homo
sapiens) 		4 / 7 LYS C  21
LYS C  24
SER B  42
ASP B  98
 None
 1.37A 2rk8B-5t5wC:
undetectable		 2rk8B-5t5wC:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		5 / 11 ALA B 141
LEU B 166
LEU B 119
SER B 177
LEU B 176
 None
 1.04A 2xn5A-5t5wB:
undetectable		 2xn5A-5t5wB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		4 / 5 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.15A 3bjwA-5t5wB:
undetectable		 3bjwA-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		4 / 5 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.21A 3bjwG-5t5wB:
undetectable		 3bjwG-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		4 / 5 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.20A 3bjwC-5t5wB:
undetectable		 3bjwC-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		4 / 5 VAL B  80
VAL B  37
THR B  11
THR B  82
 None
 1.14A 3bjwD-5t5wB:
undetectable		 3bjwD-5t5wB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5t5w INTERFERON LAMBDA-3
(Homo
sapiens) 		5 / 9 LEU C  12
LEU C 149
LEU C 100
HIS C  95
LEU C  65
 None
 1.36A 3q1eB-5t5wC:
undetectable
3q1eD-5t5wC:
undetectable		 3q1eB-5t5wC:
17.18
3q1eD-5t5wC:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		3 / 3 PHE B  36
LYS B  88
SER B  89
 None
 0.75A 3tyeB-5t5wB:
undetectable		 3tyeB-5t5wB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		5 / 10 GLN B 114
LEU B 166
LEU B 119
SER B 177
LEU B 176
 None
 1.16A 4yiaA-5t5wB:
undetectable		 4yiaA-5t5wB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens) 		4 / 5 THR B 156
THR B 151
HIS B 174
LEU B 176
 None
 1.22A 5utuH-5t5wB:
undetectable		 5utuH-5t5wB:
17.23