SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 6 PHE A 337
ILE A 340
TRP A 448
GLY A 417
GLY A 419
 None
 1.45A 2qx6A-5t5xA:
undetectable
2qx6B-5t5xA:
undetectable		 2qx6A-5t5xA:
18.90
2qx6B-5t5xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 10 GLY A  27
ALA A  28
ASN A   4
ILE A  93
ILE A 125
 None
 0.95A 3lzvA-5t5xA:
undetectable		 3lzvA-5t5xA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.04A 3u9fF-5t5xA:
undetectable		 3u9fF-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.10A 3u9fG-5t5xA:
undetectable		 3u9fG-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.03A 3u9fL-5t5xA:
undetectable		 3u9fL-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.13A 3u9fS-5t5xA:
undetectable		 3u9fS-5t5xA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
 CL  A 501 (-3.3A)
None
None
None
None
 1.03A 4fp9A-5t5xA:
undetectable		 4fp9A-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
 CL  A 501 (-3.3A)
None
None
None
None
 1.03A 4fp9C-5t5xA:
undetectable		 4fp9C-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 GLY A 258
LYS A  11
GLY A 351
ASP A 389
LEU A 385
 CL  A 501 (-3.3A)
None
None
None
None
 1.04A 4fp9F-5t5xA:
undetectable		 4fp9F-5t5xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A  14
GLU A  99
ASN A  18
 CL  A 501 (-3.3A)
CL  A 501 (-2.8A)
None
 0.74A 4imaD-5t5xA:
undetectable		 4imaD-5t5xA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A  14
GLU A  99
ASN A  18
 CL  A 501 (-3.3A)
CL  A 501 (-2.8A)
None
 0.72A 4ip7D-5t5xA:
undetectable		 4ip7D-5t5xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A 478
LEU A 479
GLU A 482
 None
 0.73A 4l3gF-5t5xA:
undetectable		 4l3gF-5t5xA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		5 / 10 TRP A 448
GLY A 417
GLY A 419
PHE A 337
ILE A 340
 None
 1.43A 5lbtA-5t5xA:
undetectable
5lbtB-5t5xA:
undetectable		 5lbtA-5t5xA:
19.63
5lbtB-5t5xA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 GLY A 250
LEU A 251
HIS A 224
 None
 0.46A 5u63A-5t5xA:
undetectable		 5u63A-5t5xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5t5x CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 GLY A 250
LEU A 251
HIS A 224
 None
 0.49A 5u63B-5t5xA:
undetectable		 5u63B-5t5xA:
21.60