SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.91A 1c9sT-5t65A:
undetectable
1c9sU-5t65A:
undetectable		 1c9sT-5t65A:
15.76
1c9sU-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.87A 1gtfL-5t65A:
undetectable
1gtfM-5t65A:
undetectable		 1gtfL-5t65A:
15.76
1gtfM-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.89A 1gtfN-5t65A:
undetectable
1gtfO-5t65A:
undetectable		 1gtfN-5t65A:
15.76
1gtfO-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.45A 1hrkB-5t65A:
undetectable		 1hrkB-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 241
SER A 261
ASP A 263
LYS A 266
 None
ACT  A 302 (-2.8A)
None
None
 1.35A 1hwiC-5t65A:
undetectable		 1hwiC-5t65A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 241
SER A 261
ASP A 263
LYS A 266
 None
ACT  A 302 (-2.8A)
None
None
 1.35A 1hwiD-5t65A:
undetectable		 1hwiD-5t65A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.24A 2hrcA-5t65A:
undetectable		 2hrcA-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.40A 2pnjB-5t65A:
undetectable		 2pnjB-5t65A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 123
GLY A 103
TYR A 129
 None
 0.60A 2vouA-5t65A:
undetectable		 2vouA-5t65A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 123
GLY A 103
TYR A 129
 None
 0.63A 2vouB-5t65A:
undetectable		 2vouB-5t65A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 123
GLY A 103
TYR A 129
 None
 0.63A 2vouC-5t65A:
undetectable		 2vouC-5t65A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.21A 3hcoB-5t65A:
undetectable		 3hcoB-5t65A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 157
SER A 125
THR A 166
VAL A 133
THR A 155
 None
 1.16A 4kyaA-5t65A:
undetectable		 4kyaA-5t65A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 157
SER A 125
THR A 166
VAL A 133
THR A 155
 None
 1.14A 4kyaE-5t65A:
undetectable		 4kyaE-5t65A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 157
SER A 125
THR A 166
VAL A 133
THR A 155
 None
 1.16A 4kyaG-5t65A:
undetectable		 4kyaG-5t65A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 118
MET A 117
TYR A 121
 None
ILE  A 300 (-3.5A)
ILE  A 300 (-4.6A)
 1.10A 4qa0B-5t65A:
undetectable		 4qa0B-5t65A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 254
TRP A 256
ILE A 248
LEU A 174
 None
 1.05A 4xo7B-5t65A:
undetectable		 4xo7B-5t65A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.87A 5eezL-5t65A:
undetectable
5eezV-5t65A:
undetectable		 5eezL-5t65A:
15.76
5eezV-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.87A 5ef1L-5t65A:
undetectable
5ef1V-5t65A:
undetectable		 5ef1L-5t65A:
15.76
5ef1V-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.87A 5ef2L-5t65A:
undetectable
5ef2V-5t65A:
undetectable		 5ef2L-5t65A:
15.76
5ef2V-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 129
VAL A 133
ASP A 131
ALA A 132
 None
 1.08A 5otrA-5t65A:
undetectable		 5otrA-5t65A:
24.23