SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 VAL A 213
GLY A 210
LEU A 209
VAL A  51
PHE A 295
 None
 1.50A 1a27A-5t67A:
5.6		 1a27A-5t67A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 MET A 179
LEU A 262
PHE A 243
ILE A 173
LEU A 196
 None
 1.12A 1dreA-5t67A:
undetectable		 1dreA-5t67A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 TYR A 407
THR A 333
VAL A 343
ILE A 338
 None
 0.98A 1p7rA-5t67A:
undetectable		 1p7rA-5t67A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 MET A 179
LEU A 262
PHE A 243
ILE A 173
LEU A 196
 None
 1.16A 1rh3A-5t67A:
2.5		 1rh3A-5t67A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 11 TYR A  76
ASP A  33
GLU A 111
HIS A 225
PHE A  72
 SAH  A 502 (-4.4A)
JHZ  A 503 ( 4.3A)
SAH  A 502 ( 4.8A)
JHZ  A 503 (-4.1A)
SAH  A 502 (-3.6A)
 1.28A 2dg3A-5t67A:
undetectable		 2dg3A-5t67A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 10 ILE A 118
HIS A 254
TYR A 174
GLU A 111
ASN A 177
 None
JHZ  A 503 (-3.8A)
None
SAH  A 502 ( 4.8A)
SAH  A 502 ( 3.7A)
 1.45A 2jkcA-5t67A:
4.0		 2jkcA-5t67A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		3 / 3 SER A 233
HIS A 225
ASP A 219
 None
JHZ  A 503 (-4.1A)
None
 0.86A 2oxtA-5t67A:
6.5		 2oxtA-5t67A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ALA A 158
THR A 159
ALA A 162
ARG A 151
 None
 0.88A 2ql8A-5t67A:
undetectable
2ql8B-5t67A:
undetectable		 2ql8A-5t67A:
16.35
2ql8B-5t67A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.91A 3g89A-5t67A:
9.8		 3g89A-5t67A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.83A 3g8bA-5t67A:
9.8		 3g8bA-5t67A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 324
ASP A 348
THR A 350
LYS A 353
GLU A 389
 JHZ  A 503 (-3.6A)
JHZ  A 503 (-2.6A)
JHZ  A 503 (-4.1A)
JHZ  A 503 (-2.9A)
JHZ  A 503 ( 3.8A)
 0.89A 3g8bB-5t67A:
9.4		 3g8bB-5t67A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 GLU A 111
VAL A 172
VAL A 123
ALA A  94
 SAH  A 502 ( 4.8A)
None
None
None
 1.05A 3kp6B-5t67A:
undetectable		 3kp6B-5t67A:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		12 / 12 PHE A  72
TYR A  76
TYR A  78
PHE A  90
GLU A 111
ILE A 112
PHE A 133
PHE A 154
PHE A 155
ALA A 176
THR A 178
ILE A 182
 SAH  A 502 (-3.6A)
SAH  A 502 (-4.4A)
JHZ  A 503 (-3.2A)
SAH  A 502 (-4.5A)
SAH  A 502 ( 4.8A)
SAH  A 502 (-4.4A)
None
SAH  A 502 (-4.9A)
None
SAH  A 502 (-3.5A)
SAH  A 502 (-3.2A)
SAH  A 502 (-4.4A)
 0.26A 3ndiA-5t67A:
66.5		 3ndiA-5t67A:
77.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_1
(METHYLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		9 / 9 SER A  80
GLY A 113
ASN A 115
GLU A 134
PRO A 135
SER A 136
ASN A 177
HIS A 181
TYR A 184
 SAH  A 502 (-2.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
SAH  A 502 (-2.7A)
SAH  A 502 (-3.9A)
SAH  A 502 (-2.8A)
SAH  A 502 ( 3.7A)
JHZ  A 503 (-3.9A)
EDO  A 506 (-3.9A)
 0.17A 3ndiA-5t67A:
66.5		 3ndiA-5t67A:
77.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ARG A 398
GLU A 394
PHE A 371
PRO A 376
 None
 1.42A 3ql6A-5t67A:
undetectable		 3ql6A-5t67A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 5 ARG A 398
GLU A 394
PHE A 371
PRO A 376
 None
 1.43A 3r4xA-5t67A:
undetectable		 3r4xA-5t67A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 5 THR A 333
ILE A 338
PHE A 382
LEU A 363
 None
 1.27A 3tf1A-5t67A:
undetectable		 3tf1A-5t67A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 TYR A  76
ASP A  33
SER A  32
TYR A  47
 SAH  A 502 (-4.4A)
JHZ  A 503 ( 4.3A)
None
None
 1.32A 4arcA-5t67A:
undetectable		 4arcA-5t67A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 8 GLY A 242
GLY A 266
VAL A 246
GLU A 244
 None
MG  A 508 ( 4.2A)
None
MG  A 508 ( 3.9A)
 0.76A 4fgzB-5t67A:
13.9		 4fgzB-5t67A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 MET A 179
LEU A 262
PHE A 243
ILE A 173
LEU A 196
 None
 1.11A 4nx6A-5t67A:
undetectable		 4nx6A-5t67A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.5A)
None
 1.01A 4qw0K-5t67A:
undetectable		 4qw0K-5t67A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 7 ALA A 325
THR A 326
ALA A 327
THR A 358
 None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.5A)
None
 1.01A 4qw0Y-5t67A:
undetectable		 4qw0Y-5t67A:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 322
ALA A 325
ARG A 319
VAL A 343
ILE A 338
 None
 0.93A 4rvdA-5t67A:
53.7		 4rvdA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		7 / 12 TYR A  76
ILE A 112
GLY A 113
PRO A 135
PHE A 155
HIS A 181
ILE A 182
 SAH  A 502 (-4.4A)
SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.9A)
None
JHZ  A 503 (-3.9A)
SAH  A 502 (-4.4A)
 0.35A 4rvdA-5t67A:
53.7		 4rvdA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A 322
ALA A 325
ARG A 319
VAL A 343
ILE A 338
 None
 0.90A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 ILE A 112
GLY A 113
ASN A 115
ALA A 140
PHE A 155
 SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
None
None
 0.84A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		7 / 12 ILE A 112
GLY A 113
ASN A 115
PRO A 135
PHE A 155
HIS A 181
ILE A 182
 SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
SAH  A 502 (-3.9A)
None
JHZ  A 503 (-3.9A)
SAH  A 502 (-4.4A)
 0.36A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 LEU A 185
ASN A 177
ALA A 175
VAL A 202
ILE A 112
 None
SAH  A 502 ( 3.7A)
None
None
SAH  A 502 (-4.4A)
 1.09A 4x1kD-5t67A:
2.1		 4x1kD-5t67A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 11 LEU A 185
ASN A 177
ALA A 175
VAL A 202
ILE A 112
 None
SAH  A 502 ( 3.7A)
None
None
SAH  A 502 (-4.4A)
 1.09A 4x20D-5t67A:
2.9		 4x20D-5t67A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 SER A  80
GLY A 113
GLU A 134
VAL A 188
ILE A 182
 SAH  A 502 (-2.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-2.7A)
None
SAH  A 502 (-4.4A)
 0.87A 5ec8A-5t67A:
6.1		 5ec8A-5t67A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 GLY A  82
TYR A  78
HIS A 254
ALA A 327
ILE A 390
 None
JHZ  A 503 (-3.2A)
JHZ  A 503 (-3.8A)
JHZ  A 503 (-3.5A)
JHZ  A 503 (-4.6A)
 1.25A 5igvA-5t67A:
undetectable		 5igvA-5t67A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		5 / 12 ASP A 219
PHE A  23
THR A 291
GLN A 284
LEU A 209
 None
 1.33A 5m54B-5t67A:
undetectable		 5m54B-5t67A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 6 GLU A 281
TYR A 208
GLY A 256
GLY A 255
 None
 0.90A 5x7pB-5t67A:
undetectable		 5x7pB-5t67A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5t67 SUGAR 3-C-METHYL
TRANSFERASE
(Actinomadura
kijaniata) 		4 / 6 PHE A  90
SER A  83
HIS A 386
HIS A 254
 SAH  A 502 (-4.5A)
None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.8A)
 1.46A 5ycnA-5t67A:
undetectable		 5ycnA-5t67A:
21.52