SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 9 ILE A 293
LEU A 345
VAL A 243
GLY A 321
ALA A 297
 None
 1.28A 1e7aA-5t6oA:
undetectable		 1e7aA-5t6oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 11 THR A 472
VAL A 325
VAL A 315
LEU A 465
ILE A 468
 None
 1.43A 1t6zB-5t6oA:
undetectable		 1t6zB-5t6oA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 321
GLY A 322
VAL A 343
LEU A 345
LEU A 274
 None
 1.01A 1ya4B-5t6oA:
4.2		 1ya4B-5t6oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		4 / 5 ALA A 297
TRP A 277
LEU A 274
ALA A 300
 None
 1.08A 2jstA-5t6oA:
undetectable
2jstB-5t6oA:
undetectable		 2jstA-5t6oA:
9.77
2jstB-5t6oA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 THR A 327
ALA A 330
ILE A 474
LEU A 350
PRO A 453
 None
 1.07A 2qxsA-5t6oA:
undetectable		 2qxsA-5t6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 THR A 327
ALA A 330
ILE A 474
LEU A 350
PRO A 453
 None
 1.03A 2qxsB-5t6oA:
undetectable		 2qxsB-5t6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		4 / 6 PRO A 433
SER A 287
TYR A 292
CYH A 246
 None
 1.37A 2x7hA-5t6oA:
2.1		 2x7hA-5t6oA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 345
VAL A 243
VAL A 320
GLY A 321
THR A 327
 None
 1.14A 3bf1A-5t6oA:
undetectable
3bf1B-5t6oA:
undetectable		 3bf1A-5t6oA:
19.79
3bf1B-5t6oA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 9 LEU A 346
PHE A 318
ILE A 252
GLY A 511
TYR A 475
 None
 1.42A 3oshA-5t6oA:
undetectable		 3oshA-5t6oA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 10 LEU A 274
GLY A 582
ALA A 580
VAL A 209
VAL A 262
 None
 1.02A 3oxwA-5t6oA:
undetectable		 3oxwA-5t6oA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 10 LEU A 274
GLY A 582
ALA A 580
VAL A 209
VAL A 262
 None
 0.99A 3oxwC-5t6oA:
undetectable		 3oxwC-5t6oA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 427
ALA A 429
ALA A 589
LEU A 390
ASN A 400
 None
 1.18A 3p5nA-5t6oA:
undetectable		 3p5nA-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 329
THR A 327
GLY A 322
LEU A 241
LEU A 345
 None
 1.12A 3p5nA-5t6oA:
undetectable		 3p5nA-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 329
THR A 327
GLY A 322
LEU A 241
LEU A 345
 None
 1.13A 3p5nB-5t6oA:
undetectable		 3p5nB-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 511
LEU A 253
PHE A 394
ILE A 482
THR A 347
 None
 1.01A 3pwwA-5t6oA:
undetectable		 3pwwA-5t6oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		4 / 6 ILE A 247
TYR A 445
TYR A 440
PHE A 396
 None
 1.23A 4g10A-5t6oA:
undetectable		 4g10A-5t6oA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 VAL A 512
PHE A 318
LEU A 345
LEU A 346
LEU A 240
 None
 1.20A 4i1rA-5t6oA:
undetectable		 4i1rA-5t6oA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 9 ASP A 254
PRO A 579
ALA A 215
TYR A 228
GLY A 206
 None
 1.26A 4mm5A-5t6oA:
undetectable		 4mm5A-5t6oA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 9 ASP A 254
PRO A 579
ALA A 215
TYR A 228
GLY A 206
 None
 1.26A 4mmbA-5t6oA:
undetectable		 4mmbA-5t6oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 10 ASP A 254
PRO A 579
ALA A 215
TYR A 228
GLY A 206
 None
 1.31A 4mmdA-5t6oA:
undetectable		 4mmdA-5t6oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		3 / 3 SER A 287
TYR A 292
ASP A 281
 None
 0.72A 4rp8C-5t6oA:
undetectable		 4rp8C-5t6oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 ILE A 324
TYR A 440
THR A 430
ASN A 279
ILE A 247
 None
 1.42A 4xe0A-5t6oA:
undetectable		 4xe0A-5t6oA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 ILE A 513
GLY A 511
ARG A 521
PHE A 318
THR A 393
 None
 1.40A 5fhzA-5t6oA:
undetectable		 5fhzA-5t6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.01A 5vooC-5t6oA:
undetectable		 5vooC-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.05A 5vooD-5t6oA:
undetectable		 5vooD-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.03A 5vooE-5t6oA:
undetectable		 5vooE-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.03A 5vooF-5t6oA:
undetectable		 5vooF-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 GLY A 206
ASP A 254
VAL A 266
LEU A 231
GLY A 214
 None
 1.04A 5vopB-5t6oA:
undetectable		 5vopB-5t6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE
(Cupriavidus
necator) 		5 / 12 TYR A 437
ILE A 247
TYR A 292
GLY A 434
LEU A 441
 None
 1.19A 5zwrA-5t6oA:
undetectable		 5zwrA-5t6oA:
25.17