SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5t6u CATHEPSIN K
(Mus
musculus) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 163
GLY A  65
 None
 1.16A 1stfE-5t6uA:
34.7
1stfI-5t6uA:
undetectable		 1stfE-5t6uA:
42.27
1stfI-5t6uA:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5t6u CATHEPSIN K
(Mus
musculus) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 None
 0.38A 1stfE-5t6uA:
34.7
1stfI-5t6uA:
undetectable		 1stfE-5t6uA:
42.27
1stfI-5t6uA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5t6u CATHEPSIN K
(Mus
musculus) 		3 / 3 ASP A 136
ASP A 158
ASP A 152
 None
 0.60A 2igtA-5t6uA:
undetectable		 2igtA-5t6uA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5t6u CATHEPSIN K
(Mus
musculus) 		4 / 8 HIS A 177
ILE A   5
ASP A   6
ARG A   8
 None
 1.07A 2v57A-5t6uA:
undetectable		 2v57A-5t6uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5t6u CATHEPSIN K
(Mus
musculus) 		4 / 8 HIS A 177
ILE A   5
ASP A   6
ARG A   8
 None
 1.06A 2v57C-5t6uA:
undetectable		 2v57C-5t6uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5t6u CATHEPSIN K
(Mus
musculus) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 None
 0.35A 3ai8A-5t6uA:
28.1		 3ai8A-5t6uA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5t6u CATHEPSIN K
(Mus
musculus) 		4 / 7 GLN A  76
TYR A 110
PRO A 213
GLN A  37
 None
 1.23A 3l2vA-5t6uA:
undetectable		 3l2vA-5t6uA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5t6u CATHEPSIN K
(Mus
musculus) 		5 / 9 ALA A  27
PRO A  50
GLN A  51
GLY A  91
SER A  24
 None
 1.34A 4a3uA-5t6uA:
undetectable		 4a3uA-5t6uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5t6u CATHEPSIN K
(Mus
musculus) 		3 / 3 TYR A 150
ASP A 136
ASP A 152
 None
 0.79A 5x6yA-5t6uA:
undetectable		 5x6yA-5t6uA:
13.81