SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 SER A  77
GLU A 139
ASP A  34
 None
 0.90A 2avdB-5t76A:
undetectable		 2avdB-5t76A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 LYS A 120
LEU A 121
GLU A 117
LEU A  86
 None
 1.32A 4k4yA-5t76A:
2.1		 4k4yA-5t76A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 4 LYS A 120
LEU A 121
GLU A 117
LEU A  86
 None
 1.35A 4k4yE-5t76A:
undetectable		 4k4yE-5t76A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 LYS A 120
LEU A 121
GLU A 117
LEU A  86
 None
 1.33A 4k4yI-5t76A:
2.1		 4k4yI-5t76A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A  94
LYS A  88
LEU A 104
 None
 1.03A 4ptjA-5t76A:
undetectable		 4ptjA-5t76A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 186
MET A 171
ASN A 188
LEU A 170
ALA A 195
 None
 1.12A 5kbwA-5t76A:
undetectable		 5kbwA-5t76A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 192
GLY A 186
MET A 171
ASN A 188
LEU A 170
 None
 1.09A 5kbwA-5t76A:
undetectable		 5kbwA-5t76A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5t76 ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A 186
MET A 171
ASN A 188
LEU A 170
ALA A 195
 None
 1.11A 5kc4E-5t76A:
undetectable		 5kc4E-5t76A:
22.42