SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 8 LEU A 377
ALA A 393
PHE A 381
VAL A 390
 None
None
OLC  A 531 ( 4.4A)
None
 0.88A 1epbB-5t77A:
undetectable		 1epbB-5t77A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 7 PHE A 364
THR A 224
VAL A 227
ALA A 367
 OLC  A 529 (-3.1A)
OLC  A 539 ( 2.5A)
OLC  A 530 ( 4.5A)
OLC  A 530 (-2.9A)
 1.09A 1fo4B-5t77A:
undetectable		 1fo4B-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 ASP A  25
TYR A 249
ILE A 313
SER A 324
PHE A 322
 None
 1.48A 1xmuA-5t77A:
undetectable		 1xmuA-5t77A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 7 SER A 353
GLY A 345
THR A 298
ILE A 420
 None
 0.74A 2bdmA-5t77A:
undetectable		 2bdmA-5t77A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		3 / 3 PHE A 457
ASN A 423
PHE A 461
 None
 0.93A 2zbuD-5t77A:
undetectable		 2zbuD-5t77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 7 VAL A 266
SER A 348
THR A 270
LEU A 273
 None
 1.16A 3arrA-5t77A:
undetectable		 3arrA-5t77A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 PHE A 184
THR A 181
PHE A 109
ILE A 106
LEU A 125
 None
 1.31A 3iv6B-5t77A:
undetectable		 3iv6B-5t77A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 PHE A 184
THR A 181
PHE A 109
ILE A 106
LEU A 125
 None
 1.37A 3iv6C-5t77A:
undetectable		 3iv6C-5t77A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 ILE A 106
ALA A  44
LEU A 120
ILE A 119
LEU A 125
 None
 1.03A 4k6iA-5t77A:
undetectable		 4k6iA-5t77A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 9 LEU A 156
ILE A 163
ILE A 160
PHE A  23
GLY A  21
 OLC  A 527 ( 4.5A)
None
OLC  A 527 ( 4.7A)
OLC  A 536 (-3.3A)
None
 1.08A 4kukA-5t77A:
undetectable		 4kukA-5t77A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		5 / 12 ILE A 160
GLY A 183
GLY A 187
ARG A  24
LEU A 171
 OLC  A 527 ( 4.7A)
OLC  A 525 ( 3.3A)
None
CL  A 501 ( 4.8A)
OLC  A 525 ( 3.9A)
 1.11A 4mwzA-5t77A:
undetectable		 4mwzA-5t77A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 GLY A 345
PRO A 413
THR A 349
THR A 298
 None
1PE  A 512 ( 4.3A)
None
None
 1.10A 5h5fA-5t77A:
undetectable		 5h5fA-5t77A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 7 ILE A  45
PHE A  49
ASP A  25
SER A 254
 None
 1.40A 5nr3A-5t77A:
undetectable		 5nr3A-5t77A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 ALA A 391
SER A 395
GLY A 340
TYR A 257
 None
 0.99A 5yodB-5t77A:
undetectable		 5yodB-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 ALA A 336
SER A 395
GLY A 340
TYR A 257
 OLC  A 535 ( 3.7A)
None
None
None
 1.18A 5yodD-5t77A:
undetectable		 5yodD-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 ALA A 391
SER A 395
GLY A 340
TYR A 257
 None
 0.86A 5yodD-5t77A:
undetectable		 5yodD-5t77A:
16.39