SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 7 LEU A 148
VAL A 161
GLY A 162
VAL A 123
 None
 0.96A 1t88A-5t7dA:
undetectable		 1t88A-5t7dA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 LEU A 148
VAL A 161
GLY A 162
VAL A 123
 None
 0.88A 2a1oA-5t7dA:
undetectable		 2a1oA-5t7dA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		3 / 3 ASP A 167
PHE A 168
LEU A 170
 None
 0.74A 2zi9A-5t7dA:
undetectable		 2zi9A-5t7dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		6 / 12 ALA A  13
ILE A  71
ASP A  17
LEU A 102
ILE A  10
THR A  14
 None
None
None
ACO  A 800 (-4.9A)
None
None
 1.24A 3qfxA-5t7dA:
undetectable		 3qfxA-5t7dA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		6 / 12 ALA A  13
ILE A  71
ASP A  17
LEU A 102
ILE A  10
THR A  14
 None
None
None
ACO  A 800 (-4.9A)
None
None
 1.24A 3qfxB-5t7dA:
undetectable		 3qfxB-5t7dA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 LEU A 110
VAL A 180
TYR A  57
LEU A 114
 None
 0.93A 3v81C-5t7dA:
undetectable		 3v81C-5t7dA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 8 LEU A 110
VAL A 180
TYR A  57
LEU A 114
 None
 0.94A 4q0bA-5t7dA:
undetectable		 4q0bA-5t7dA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 114
GLY A  75
GLU A  88
VAL A 122
GLY A  70
 None
 1.29A 5f9zA-5t7dA:
undetectable		 5f9zA-5t7dA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 5 SER A  94
VAL A  93
GLY A  70
ALA A  69
 None
ACO  A 800 (-3.9A)
None
None
 0.90A 5k50A-5t7dA:
undetectable		 5k50A-5t7dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5t7d PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE
(Streptomyces
hygroscopicus) 		4 / 6 VAL A  25
ASN A  26
PRO A  40
GLU A  45
 None
 1.23A 6h7uA-5t7dA:
undetectable		 6h7uA-5t7dA:
17.16