SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t82'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5t82 REVERSE
TRANSCRIPTASE
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 293
LEU A 279
GLN A 278
LYS A 281
VAL A 254
 None
 1.09A 3ix9A-5t82A:
undetectable		 3ix9A-5t82A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5t82 REVERSE
TRANSCRIPTASE
(Human
immunodeficiency
virus
1) 		4 / 7 GLU A 305
LEU A 303
LEU A 279
LEU A 260
 None
 0.71A 4wg0B-5t82A:
undetectable
4wg0C-5t82A:
undetectable		 4wg0B-5t82A:
10.23
4wg0C-5t82A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5t82 REVERSE
TRANSCRIPTASE
(Human
immunodeficiency
virus
1) 		4 / 7 LEU A 279
LEU A 260
GLU A 305
LEU A 303
 None
 0.71A 4wg0L-5t82A:
undetectable
4wg0M-5t82A:
undetectable		 4wg0L-5t82A:
10.23
4wg0M-5t82A:
10.23