SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 109
ILE A 137
THR A 123
THR A 145
ILE A 144
 None
None
TRS  A 706 ( 3.9A)
None
TRS  A 706 (-3.6A)
 1.37A 1i18A-5t88A:
undetectable
1i18B-5t88A:
undetectable		 1i18A-5t88A:
11.32
1i18B-5t88A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 THR A 145
ILE A 144
LEU A 109
ILE A 137
THR A 123
 None
TRS  A 706 (-3.6A)
None
None
TRS  A 706 ( 3.9A)
 1.36A 1i18A-5t88A:
undetectable
1i18B-5t88A:
undetectable		 1i18A-5t88A:
11.32
1i18B-5t88A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 TYR A 522
ILE A 504
PRO A 539
PHE A 454
 None
 1.25A 1oniA-5t88A:
undetectable
1oniC-5t88A:
undetectable		 1oniA-5t88A:
12.50
1oniC-5t88A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 THR A 340
PHE A 319
SER A 341
PHE A 385
VAL A 298
 None
 1.26A 1q23A-5t88A:
undetectable
1q23B-5t88A:
undetectable		 1q23A-5t88A:
15.10
1q23B-5t88A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 1.05A 1wrkB-5t88A:
undetectable		 1wrkB-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 0.93A 1wrlA-5t88A:
undetectable
1wrlB-5t88A:
undetectable		 1wrlA-5t88A:
9.63
1wrlB-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 0.94A 1wrlB-5t88A:
undetectable		 1wrlB-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 399
PHE A 413
MET A 411
SER A 324
 None
 1.00A 1wrlE-5t88A:
undetectable		 1wrlE-5t88A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 389
PHE A 426
GLY A 424
GLY A 423
PHE A 399
 None
 1.02A 2dpmA-5t88A:
undetectable		 2dpmA-5t88A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 450
GLY A 480
PRO A 502
 None
 0.94A 2hreB-5t88A:
undetectable		 2hreB-5t88A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 420
GLY A 365
ILE A 344
VAL A 416
ILE A 417
 None
 0.98A 2ienB-5t88A:
undetectable		 2ienB-5t88A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 600
GLU A 603
SER A 114
 CL  A 701 ( 3.0A)
CL  A 702 (-3.2A)
None
 0.76A 2xctD-5t88A:
undetectable		 2xctD-5t88A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 ASP A 177
VAL A 184
ARG A 182
TYR A 152
 None
 1.13A 2yfbA-5t88A:
undetectable		 2yfbA-5t88A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 177
VAL A 184
ARG A 182
TYR A 152
 None
 1.09A 2yfbB-5t88A:
undetectable		 2yfbB-5t88A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 420
GLY A 365
ILE A 344
VAL A 416
ILE A 417
 None
 0.98A 3d1xB-5t88A:
undetectable		 3d1xB-5t88A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 568
GLY A 475
ILE A 504
VAL A 483
SER A 484
 None
 1.16A 3gyqB-5t88A:
3.2		 3gyqB-5t88A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 481
GLY A 475
ILE A 504
VAL A 483
SER A 484
 None
 1.22A 3gyqB-5t88A:
3.2		 3gyqB-5t88A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 399
PHE A 426
GLY A 500
PHE A 342
 None
 1.11A 3ko0R-5t88A:
undetectable
3ko0T-5t88A:
undetectable		 3ko0R-5t88A:
11.29
3ko0T-5t88A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 339
LEU A 337
LEU A 304
SER A 301
 None
 0.97A 3lm8B-5t88A:
undetectable
3lm8D-5t88A:
2.2		 3lm8B-5t88A:
16.45
3lm8D-5t88A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_C_ACTC120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 279
LYS A 313
GLU A 316
LYS A 303
GLU A 305
 None
 1.12A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_C_ACTC120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 279
LYS A 313
GLU A 316
LYS A 303
GLU A 305
 None
 1.13A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_C_ACTC120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LYS A 313
GLU A 316
LYS A 303
GLU A 305
GLU A 279
 None
 1.11A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 420
GLY A 365
ILE A 344
VAL A 416
ILE A 417
 None
 0.99A 3nduB-5t88A:
undetectable		 3nduB-5t88A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 420
GLY A 365
ILE A 344
VAL A 416
ILE A 417
 None
 0.94A 3pwrB-5t88A:
undetectable		 3pwrB-5t88A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 583
LEU A  17
LYS A  18
 None
 0.61A 3sueD-5t88A:
undetectable		 3sueD-5t88A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 ASP A 561
ASP A 560
GLY A 591
THR A 588
 None
 1.09A 3tl9B-5t88A:
undetectable		 3tl9B-5t88A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 PHE A 533
TYR A 522
TYR A 537
 None
 1.02A 4ffwA-5t88A:
23.8		 4ffwA-5t88A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 THR A 614
LEU A 487
LEU A 461
GLU A 462
 None
 0.78A 4nc3A-5t88A:
undetectable		 4nc3A-5t88A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 VAL A 483
LEU A 482
LEU A 461
PHE A 419
 None
 1.01A 4o1zA-5t88A:
undetectable		 4o1zA-5t88A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 SER A 112
THR A 101
GLU A 104
ASP A 329
TYR A 151
 TRS  A 706 (-2.7A)
TRS  A 706 (-4.0A)
None
None
None
 1.49A 4qb9C-5t88A:
undetectable		 4qb9C-5t88A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 382
GLY A 402
GLY A 434
LEU A 482
VAL A 453
 None
 0.97A 4qdjA-5t88A:
undetectable		 4qdjA-5t88A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 285
LEU A 293
LEU A 304
LEU A 325
LEU A 337
 None
 1.06A 4wg0G-5t88A:
undetectable
4wg0H-5t88A:
undetectable
4wg0I-5t88A:
undetectable		 4wg0G-5t88A:
2.45
4wg0H-5t88A:
2.45
4wg0I-5t88A:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 152
THR A 154
THR A 145
 None
 0.68A 5aoxB-5t88A:
undetectable		 5aoxB-5t88A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 LEU A 293
ILE A 292
GLY A 295
ILE A 263
 None
 0.89A 5dzk3-5t88A:
undetectable
5dzkm-5t88A:
undetectable		 5dzk3-5t88A:
2.06
5dzkm-5t88A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 ILE A 207
LYS A 267
ILE A 266
VAL A 233
 None
 0.90A 5jmnA-5t88A:
undetectable		 5jmnA-5t88A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 442
GLU A 439
TRP A 214
 None
 1.20A 5odiD-5t88A:
2.7		 5odiD-5t88A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 HIS A 442
GLU A 439
TRP A 214
 None
 1.22A 5odqD-5t88A:
2.7		 5odqD-5t88A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 475
ILE A 504
LEU A 481
GLY A 479
GLY A 480
 None
 1.11A 5wyqA-5t88A:
2.6		 5wyqA-5t88A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5t88 PROLYL ENDOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 PRO A 223
MET A 173
GLY A 186
VAL A 208
 None
 1.48A 6ak3A-5t88A:
undetectable		 6ak3A-5t88A:
9.26