SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		5 / 11 ILE A 216
LEU A 171
ILE A 202
PHE A 237
ILE A 249
 None
 1.03A 1dyrA-5t8dA:
undetectable		 1dyrA-5t8dA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		4 / 7 VAL A 272
TRP A 269
PHE A 242
GLU A 184
 None
 1.44A 1k2tA-5t8dA:
undetectable
1k2tB-5t8dA:
undetectable		 1k2tA-5t8dA:
21.27
1k2tB-5t8dA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		4 / 7 PHE A 200
LEU A 171
PHE A 181
VAL A 261
 None
 1.12A 1wrlA-5t8dA:
undetectable
1wrlB-5t8dA:
undetectable		 1wrlA-5t8dA:
15.05
1wrlB-5t8dA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		4 / 7 VAL A 272
TRP A 269
PHE A 242
GLU A 184
 None
 1.39A 3q99A-5t8dA:
undetectable
3q99B-5t8dA:
undetectable		 3q99A-5t8dA:
21.32
3q99B-5t8dA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		5 / 12 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 402 (-4.7A)
None
 1.05A 3sudB-5t8dA:
undetectable		 3sudB-5t8dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		5 / 11 VAL A 252
PHE A 253
PHE A 237
GLY A 220
LEU A 171
 None
 0.97A 3t3rA-5t8dA:
undetectable		 3t3rA-5t8dA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5t8d I-ONUI_E-VHIVINT_V2
(synthetic
construct) 		5 / 9 ALA A  19
VAL A  89
THR A  63
ILE A  47
VAL A  66
 None
 1.07A 4r21B-5t8dA:
undetectable		 4r21B-5t8dA:
19.16