SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 12 ILE A  65
PHE A 120
LEU A 174
LEU A 230
PHE A 118
 None
 1.09A 1og5B-5t8uA:
undetectable		 1og5B-5t8uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 10 GLY A 107
HIS A 111
THR A 104
HIS A 176
ILE A  76
 LPA  A 401 (-4.2A)
LPA  A 401 (-4.3A)
None
LPA  A 401 (-3.6A)
LPA  A 401 ( 4.2A)
 1.26A 2y7wB-5t8uA:
undetectable		 2y7wB-5t8uA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 8 ILE A  32
ASN A  29
SER A  27
SER A  37
 None
 1.14A 2zw9B-5t8uA:
undetectable		 2zw9B-5t8uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 12 SER A  74
GLY A  78
ILE A 324
ASP A 320
PHE A 166
 None
 1.34A 3a25A-5t8uA:
undetectable		 3a25A-5t8uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 12 ILE A  76
ILE A  75
ALA A 108
LEU A 183
ILE A 212
 LPA  A 401 ( 4.2A)
None
None
None
None
 0.95A 3uvvA-5t8uA:
undetectable		 3uvvA-5t8uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 8 GLN A 295
GLY A 107
ASN A 152
GLU A  86
 None
LPA  A 401 (-4.2A)
LPA  A 401 (-4.6A)
None
 0.92A 4fgjA-5t8uA:
undetectable
4fgjB-5t8uA:
undetectable		 4fgjA-5t8uA:
20.38
4fgjB-5t8uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 8 ASN A 218
LEU A 214
ASN A 213
ILE A 212
 None
 1.00A 4k0bA-5t8uA:
undetectable		 4k0bA-5t8uA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 8 ASN A 218
LEU A 214
ASN A 213
ILE A 212
 None
 1.01A 4l7iA-5t8uA:
undetectable		 4l7iA-5t8uA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8A-5t8uA:
undetectable		 5hm8A-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8B-5t8uA:
undetectable		 5hm8B-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8C-5t8uA:
undetectable		 5hm8C-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8D-5t8uA:
undetectable		 5hm8D-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8E-5t8uA:
undetectable		 5hm8E-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8F-5t8uA:
undetectable		 5hm8F-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		4 / 5 GLU A 239
GLU A 233
THR A 137
LEU A  66
 None
 1.20A 5hm8H-5t8uA:
undetectable		 5hm8H-5t8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		3 / 3 ASN A  80
VAL A 354
HIS A 329
 None
 0.74A 6a5yD-5t8uA:
undetectable		 6a5yD-5t8uA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5t8u LIPOATE-PROTEIN
LIGASE 1
(Plasmodium
falciparum) 		5 / 12 ASN A 115
ILE A 179
ILE A 154
ILE A 134
HIS A 175
 None
 1.02A 6hlpA-5t8uA:
undetectable		 6hlpA-5t8uA:
18.35