SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 SER A 915
TRP A 962
LEU A 949
TRP A 890
None
1.42A 1agmA-5t8vA:
2.8
1agmA-5t8vA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 PHE A 796
VAL A 766
VAL A 690
ASP A 795
None
1.43A 1dz6B-5t8vA:
undetectable
1dz6B-5t8vA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 4 LYS A 544
LEU A 540
ALA A 611
LEU A 608
None
1.45A 1f86B-5t8vA:
undetectable
1f86B-5t8vA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 ALA A 514
ALA A 539
ALA A 510
VAL A 640
LEU A 608
None
0.97A 1fm6U-5t8vA:
undetectable
1fm6U-5t8vA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 PHE A 869
ALA A 889
ILE A 984
PRO A 893
None
1.17A 1oniH-5t8vA:
undetectable
1oniI-5t8vA:
0.7
1oniH-5t8vA:
7.14
1oniI-5t8vA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 11 THR A1167
TYR A1101
PHE A1233
LEU A1202
VAL A1161
None
1.22A 1q23L-5t8vA:
undetectable
1q23L-5t8vA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 GLU A1686
TRP A1762
LYS A1622
None
1.30A 1qu2A-5t8vA:
1.6
1qu2A-5t8vA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 GLN A 489
ASP A 496
GLY A 493
LEU A 557
LEU A 570
None
1.09A 1rjdA-5t8vA:
undetectable
1rjdA-5t8vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 GLN A 489
ASP A 496
GLY A 493
LEU A 557
LEU A 570
None
1.08A 1rjdB-5t8vA:
undetectable
1rjdB-5t8vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 GLN A 489
ASP A 496
GLY A 493
LEU A 557
LEU A 570
None
1.09A 1rjdC-5t8vA:
undetectable
1rjdC-5t8vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 LEU A 470
ALA A 513
LEU A 473
SER A 476
None
1.10A 1tt6B-5t8vA:
undetectable
1tt6B-5t8vA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 ALA A 950
TYR A 932
ILE A 928
ASP A 943
None
1.25A 1upfA-5t8vA:
undetectable
1upfA-5t8vA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 ALA A 514
ALA A 539
ALA A 510
VAL A 640
LEU A 608
None
1.04A 1xiuB-5t8vA:
undetectable
1xiuB-5t8vA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 LEU A 540
LEU A 594
MET A 644
None
0.78A 1ya3B-5t8vA:
undetectable
1ya3B-5t8vA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PRO A1296
VAL A1309
ILE A1253
VAL A1297
LEU A1305
None
1.43A 1z9hA-5t8vA:
3.4
1z9hA-5t8vA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PRO A1296
VAL A1309
ILE A1253
VAL A1297
LEU A1305
None
1.44A 1z9hB-5t8vA:
undetectable
1z9hB-5t8vA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PRO A1296
VAL A1309
ILE A1253
VAL A1297
LEU A1305
None
1.44A 1z9hC-5t8vA:
3.4
1z9hC-5t8vA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PHE A 990
LEU A 812
LEU A 815
GLU A 838
LEU A 839
None
1.19A 2bxfA-5t8vA:
undetectable
2bxfA-5t8vA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 ASP A 872
LEU A 873
MET A 887
ARG A 883
None
0.97A 2gj5A-5t8vA:
undetectable
2gj5A-5t8vA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 11 ILE A 767
LEU A 839
MET A 843
ASP A 795
PHE A 796
None
1.21A 2no6B-5t8vA:
undetectable
2no6B-5t8vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 11 LEU A 898
VAL A 972
ILE A 920
ALA A 977
ASP A 804
None
1.18A 2q72A-5t8vA:
undetectable
2q72A-5t8vA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PHE A 412
ALA A 411
THR A 516
LEU A 404
LEU A 471
None
1.36A 2rctA-5t8vA:
undetectable
2rctA-5t8vA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 11 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
None
1.28A 2v0mA-5t8vA:
0.0
2v0mA-5t8vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 9 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
None
1.28A 2v0mB-5t8vA:
undetectable
2v0mB-5t8vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 11 SER A1333
LEU A1313
ILE A1363
ALA A1367
LEU A1373
None
1.22A 2v0mD-5t8vA:
undetectable
2v0mD-5t8vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 LEU A 446
GLN A 447
LEU A 408
PHE A 412
None
0.94A 2zxwP-5t8vA:
3.1
2zxwW-5t8vA:
undetectable
2zxwP-5t8vA:
9.66
2zxwW-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 LEU A 540
ARG A 515
MET A 518
LEU A 594
None
CIT  A2001 (-3.0A)
None
None
1.07A 3abmA-5t8vA:
2.2
3abmJ-5t8vA:
undetectable
3abmA-5t8vA:
15.48
3abmJ-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 8 SER A1660
ALA A1753
PHE A1642
ILE A1644
None
0.94A 3bpxA-5t8vA:
undetectable
3bpxB-5t8vA:
undetectable
3bpxA-5t8vA:
7.52
3bpxB-5t8vA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A1059
LEU A1001
GLY A 841
THR A 842
LEU A1017
None
1.31A 3okxB-5t8vA:
undetectable
3okxB-5t8vA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
6 / 10 LEU A1459
ALA A1502
ASP A1499
GLY A1539
VAL A1541
VAL A1531
None
1.42A 3oxwA-5t8vA:
undetectable
3oxwA-5t8vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
6 / 10 LEU A1459
ALA A1502
ASP A1499
GLY A1539
VAL A1541
VAL A1531
None
1.40A 3oxwC-5t8vA:
undetectable
3oxwC-5t8vA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 THR A 600
VAL A 598
GLU A 533
None
0.63A 3v4tA-5t8vA:
undetectable
3v4tD-5t8vA:
undetectable
3v4tA-5t8vA:
16.05
3v4tD-5t8vA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 ARG A 512
LEU A 588
SER A 589
MET A 581
None
1.15A 4e1gA-5t8vA:
undetectable
4e1gA-5t8vA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 PHE A1243
ALA A1282
LEU A1279
LEU A1246
TYR A1272
None
1.09A 4g1bA-5t8vA:
undetectable
4g1bA-5t8vA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 7 PHE A 919
ILE A 984
TYR A 981
PRO A 806
None
1.21A 4g5jA-5t8vA:
undetectable
4g5jA-5t8vA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A1031
VAL A1037
ALA A 845
MET A1005
LEU A1057
None
1.31A 4iaqA-5t8vA:
2.9
4iaqA-5t8vA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 4 LEU A 810
PHE A 919
LEU A 985
GLU A 809
None
1.30A 4p7nA-5t8vA:
undetectable
4p7nA-5t8vA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 GLN A 976
SER A 903
ASP A 971
None
0.90A 4qwpA-5t8vA:
undetectable
4qwpB-5t8vA:
undetectable
4qwpA-5t8vA:
11.04
4qwpB-5t8vA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 GLN A1639
ILE A1663
ILE A1591
TYR A1659
None
1.25A 5dnuA-5t8vA:
undetectable
5dnuA-5t8vA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 GLN A1639
ILE A1663
ILE A1591
TYR A1659
None
1.29A 5dnvA-5t8vA:
undetectable
5dnvA-5t8vA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 4 GLN A1698
VAL A1699
GLU A1701
ILE A1700
None
1.47A 5jncA-5t8vA:
undetectable
5jncA-5t8vA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 HIS A1569
LYS A1570
PHE A1566
None
1.23A 5klaA-5t8vA:
4.1
5klaA-5t8vA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 PHE A1464
SER A1465
ASN A1175
ASP A1178
None
1.46A 5kpcA-5t8vA:
undetectable
5kpcA-5t8vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 4 GLN A1009
THR A1011
GLU A 838
LEU A1001
None
1.41A 5m66A-5t8vA:
undetectable
5m66A-5t8vA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 10 ILE A1663
ILE A1757
ALA A1760
ILE A1761
ILE A1812
None
1.01A 5mvmD-5t8vA:
4.2
5mvmE-5t8vA:
5.6
5mvmD-5t8vA:
4.09
5mvmE-5t8vA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 10 ALA A1284
LEU A1320
GLY A1321
ILE A1256
LEU A1305
None
1.17A 5oy01-5t8vA:
2.2
5oy07-5t8vA:
undetectable
5oy01-5t8vA:
4.71
5oy07-5t8vA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 LEU A1326
VAL A1330
SER A1332
LEU A1306
VAL A1298
None
1.12A 5tudA-5t8vA:
2.5
5tudA-5t8vA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 LEU A 542
LEU A 546
MET A 591
GLN A 538
None
1.33A 5uc3A-5t8vA:
undetectable
5uc3A-5t8vA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
3 / 3 ARG A 773
ARG A 675
ARG A 786
None
0.98A 5vcgA-5t8vA:
undetectable
5vcgA-5t8vA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 LEU A 540
ARG A 515
MET A 518
LEU A 594
None
CIT  A2001 (-3.0A)
None
None
1.06A 5x1fA-5t8vA:
undetectable
5x1fJ-5t8vA:
undetectable
5x1fA-5t8vA:
15.48
5x1fJ-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
5 / 12 ALA A 514
ALA A 539
ALA A 510
VAL A 640
LEU A 608
None
0.96A 5z12C-5t8vA:
undetectable
5z12C-5t8vA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 LEU A 501
ASP A 583
GLN A 447
GLU A 508
None
1.44A 6djzC-5t8vA:
undetectable
6djzC-5t8vA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 ILE A1591
SER A1590
ALA A1565
LEU A1616
None
0.92A 6dwnA-5t8vA:
undetectable
6dwnA-5t8vA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 8 PHE A 649
VAL A 766
SER A 764
TYR A 765
None
1.12A 6huoC-5t8vA:
2.8
6huoD-5t8vA:
3.5
6huoC-5t8vA:
4.19
6huoD-5t8vA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 6 GLN A1589
PHE A1592
LEU A1614
PHE A1670
None
1.34A 6nmpC-5t8vA:
2.6
6nmpJ-5t8vA:
undetectable
6nmpC-5t8vA:
9.66
6nmpJ-5t8vA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum)
4 / 5 ILE A1253
LEU A1294
ARG A1247
LEU A1276
None
0.90A 6nmpN-5t8vA:
undetectable
6nmpW-5t8vA:
undetectable
6nmpN-5t8vA:
15.48
6nmpW-5t8vA:
3.22