SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 11 ASN A 175
ILE A 127
THR A 129
LEU A 120
VAL A   3
 None
 1.32A 1tw4A-5t8yA:
undetectable		 1tw4A-5t8yA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 MET A 172
ALA A 170
ILE A  73
ASP A 114
 None
 1.08A 1upfA-5t8yA:
undetectable		 1upfA-5t8yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 MET A 172
ALA A 170
ILE A  73
ASP A 114
 None
 0.91A 1upfC-5t8yA:
undetectable		 1upfC-5t8yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 12 THR A 174
VAL A 143
ALA A 147
ALA A  27
ILE A  73
 None
 1.20A 3dl9B-5t8yA:
undetectable		 3dl9B-5t8yA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 12 LEU A 169
GLY A 150
PRO A 161
ALA A 147
ASP A 181
 B12  A 503 (-4.1A)
None
None
None
None
 1.20A 3i5uA-5t8yA:
undetectable		 3i5uA-5t8yA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 12 LEU A 169
GLY A 150
PRO A 161
ALA A 147
ASP A 181
 B12  A 503 (-4.1A)
None
None
None
None
 1.16A 3i5uB-5t8yA:
undetectable		 3i5uB-5t8yA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.22A 3w9tA-5t8yA:
undetectable		 3w9tA-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.20A 3w9tB-5t8yA:
undetectable		 3w9tB-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.21A 3w9tC-5t8yA:
undetectable		 3w9tC-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.20A 3w9tD-5t8yA:
undetectable		 3w9tD-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.21A 3w9tE-5t8yA:
undetectable		 3w9tE-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.21A 3w9tF-5t8yA:
undetectable		 3w9tF-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 5 ASP A 104
VAL A 290
GLY A 292
TYR A 105
 None
None
None
B12  A 503 (-4.7A)
 1.21A 3w9tG-5t8yA:
undetectable		 3w9tG-5t8yA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		3 / 3 TYR A 105
GLN A 220
TRP A 101
 B12  A 503 (-4.7A)
B12  A 503 ( 4.3A)
None
 0.92A 4kn2C-5t8yA:
undetectable		 4kn2C-5t8yA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 10 CYH A 156
LEU A 209
CYH A 194
LEU A 203
ALA A 202
 B12  A 503 ( 4.5A)
B12  A 503 ( 3.9A)
SF4  A 501 (-2.2A)
SF4  A 502 ( 4.6A)
SF4  A 502 ( 3.9A)
 1.07A 4p65A-5t8yA:
undetectable
4p65B-5t8yA:
undetectable
4p65F-5t8yA:
undetectable
4p65H-5t8yA:
undetectable		 4p65A-5t8yA:
3.62
4p65B-5t8yA:
5.66
4p65F-5t8yA:
5.66
4p65H-5t8yA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 11 CYH A 156
LEU A 209
CYH A 194
LEU A 203
ALA A 202
 B12  A 503 ( 4.5A)
B12  A 503 ( 3.9A)
SF4  A 501 (-2.2A)
SF4  A 502 ( 4.6A)
SF4  A 502 ( 3.9A)
 1.06A 4p65C-5t8yA:
undetectable
4p65D-5t8yA:
undetectable
4p65J-5t8yA:
undetectable
4p65L-5t8yA:
undetectable		 4p65C-5t8yA:
3.62
4p65D-5t8yA:
5.66
4p65J-5t8yA:
5.66
4p65L-5t8yA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		4 / 4 CYH A 156
LEU A 209
LEU A 203
ALA A 202
 B12  A 503 ( 4.5A)
B12  A 503 ( 3.9A)
SF4  A 502 ( 4.6A)
SF4  A 502 ( 3.9A)
 1.03A 5hpuA-5t8yA:
undetectable
5hpuB-5t8yA:
undetectable		 5hpuA-5t8yA:
3.62
5hpuB-5t8yA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		5 / 10 HIS A 106
ALA A  76
GLY A 164
THR A 159
ALA A  74
 PO4  A 505 ( 4.6A)
None
None
None
None
 1.33A 5vyhA-5t8yA:
undetectable		 5vyhA-5t8yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5t8y EPOXYQUEUOSINE
REDUCTASE
(Bacillus
subtilis) 		3 / 3 LYS A 253
ASN A 250
SER A 165
 None
 1.25A 5yw0A-5t8yA:
undetectable		 5yw0A-5t8yA:
23.23