SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR6_A_DM2A2002_1
(ACRB)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 9 GLN A 130
GLN A 184
GLY A 229
PHE A  20
PHE A  23
 TYR  A 302 (-4.0A)
TYR  A 302 (-3.5A)
None
NAP  A 301 (-3.6A)
None
 1.02A 2dr6A-5t95A:
2.6		 2dr6A-5t95A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		4 / 8 HIS A 176
SER A 101
LEU A  24
ASP A  98
 None
NAP  A 301 ( 2.5A)
None
None
 1.19A 3n2oC-5t95A:
undetectable
3n2oD-5t95A:
3.0		 3n2oC-5t95A:
18.47
3n2oD-5t95A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 11 ALA A  37
PHE A  54
GLY A  18
THR A  73
VAL A  81
 None
None
NAP  A 301 (-3.4A)
NAP  A 301 (-4.1A)
NAP  A 301 (-4.7A)
 1.07A 3rukD-5t95A:
undetectable		 3rukD-5t95A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 PHE A  23
GLY A 128
ASP A 222
GLY A  21
SER A  77
 None
TYR  A 302 ( 3.1A)
TYR  A 302 ( 2.9A)
None
NAP  A 301 (-3.5A)
 1.05A 3sudB-5t95A:
undetectable		 3sudB-5t95A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 PHE A  23
GLY A 128
ASP A 222
GLY A  21
SER A  77
 None
TYR  A 302 ( 3.1A)
TYR  A 302 ( 2.9A)
None
NAP  A 301 (-3.5A)
 1.06A 3sueD-5t95A:
undetectable		 3sueD-5t95A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 ILE A  14
GLY A  13
ALA A  64
HIS A  33
ILE A  52
 None
 0.92A 4rvdA-5t95A:
4.6		 4rvdA-5t95A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 12 GLU A 164
LEU A  10
SER A   9
VAL A  70
VAL A  97
 None
 0.92A 5dpdA-5t95A:
4.5		 5dpdA-5t95A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 9 VAL A  97
PHE A 157
ILE A  12
TRP A 136
LEU A  24
 None
 1.41A 5e4dA-5t95A:
undetectable		 5e4dA-5t95A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		5 / 9 VAL A  99
VAL A  97
PHE A 157
ILE A  12
LEU A  24
 None
 1.24A 5e4dA-5t95A:
undetectable		 5e4dA-5t95A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5t95 PREPHENATE
DEHYDROGENASE 1
(Glycine
max) 		4 / 5 LEU A 212
THR A 211
THR A 206
GLY A 208
 None
 1.22A 6gtqA-5t95A:
undetectable		 6gtqA-5t95A:
21.20