SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 ILE E 227
ALA E 223
MET E 216
MET E 219
LEU E 256
 None
 1.01A 2h77A-5t9cE:
undetectable		 2h77A-5t9cE:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 GLU E 152
HIS E  43
GLU E  70
 CA  E 301 ( 3.2A)
G3P  E 302 ( 4.0A)
CA  E 301 ( 2.9A)
 0.53A 2x45B-5t9cE:
undetectable		 2x45B-5t9cE:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 GLU E 152
HIS E  43
GLU E  70
 CA  E 301 ( 3.2A)
G3P  E 302 ( 4.0A)
CA  E 301 ( 2.9A)
 0.56A 2x45C-5t9cE:
undetectable		 2x45C-5t9cE:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 8 LYS E 192
GLN E 209
GLU E 226
GLU E 193
 None
 1.29A 3dh0A-5t9cE:
undetectable		 3dh0A-5t9cE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 SER E 189
TYR E 230
ILE E 227
ALA E 223
GLU E 226
 None
 1.25A 3u6tA-5t9cE:
undetectable		 3u6tA-5t9cE:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 ASP E 141
VAL E 139
HIS E 173
GLY E 144
ALA E 147
 None
 1.23A 3ucjA-5t9cE:
undetectable		 3ucjA-5t9cE:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY E 233
THR E 207
VAL E 275
PRO E 236
LEU E 241
 None
 1.17A 3v8vA-5t9cE:
undetectable		 3v8vA-5t9cE:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 TYR E 259
ARG E  44
HIS E  85
 G3P  E 302 (-3.8A)
G3P  E 302 (-3.8A)
G3P  E 302 (-3.8A)
 1.17A 4fubA-5t9cE:
undetectable		 4fubA-5t9cE:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 LEU E  32
ALA E  61
TYR E 150
ILE E 186
GLY E 233
 None
 1.17A 4l9qA-5t9cE:
undetectable		 4l9qA-5t9cE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 LEU E  32
ALA E  61
TYR E 150
ILE E 186
GLY E 233
 None
 1.18A 4l9qB-5t9cE:
undetectable		 4l9qB-5t9cE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ARG E  44
HIS E  53
SER E  47
 G3P  E 302 (-3.8A)
None
PO4  E 303 ( 4.8A)
 0.77A 4mjwA-5t9cE:
undetectable
4mjwB-5t9cE:
undetectable		 4mjwA-5t9cE:
19.61
4mjwB-5t9cE:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 SER E  47
ARG E  44
HIS E  53
 PO4  E 303 ( 4.8A)
G3P  E 302 (-3.8A)
None
 0.76A 4mjwA-5t9cE:
undetectable
4mjwB-5t9cE:
undetectable		 4mjwA-5t9cE:
19.61
4mjwB-5t9cE:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 LYS E 181
PRO E 182
LYS E  31
 None
 1.21A 5y9yA-5t9cE:
undetectable		 5y9yA-5t9cE:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 6 LEU E 195
TYR E 259
ASP E  72
GLU E 152
 None
G3P  E 302 (-3.8A)
CA  E 301 ( 2.9A)
CA  E 301 ( 3.2A)
 1.13A 6djzC-5t9cE:
undetectable		 6djzC-5t9cE:
22.78