SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		4 / 5 SER A  32
ASN A  30
ALA A 135
GLU A 134
 MG  A 608 ( 4.8A)
MG  A 608 ( 3.9A)
MG  A 608 ( 4.2A)
MG  A 608 (-1.7A)
 1.20A 1lqtA-5t9jA:
undetectable
1lqtB-5t9jA:
undetectable		 1lqtA-5t9jA:
20.22
1lqtB-5t9jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		4 / 5 SER A  32
ASN A  30
ALA A 135
GLU A 134
 MG  A 608 ( 4.8A)
MG  A 608 ( 3.9A)
MG  A 608 ( 4.2A)
MG  A 608 (-1.7A)
 1.20A 1lquA-5t9jA:
undetectable
1lquB-5t9jA:
undetectable		 1lquA-5t9jA:
20.22
1lquB-5t9jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		4 / 7 LEU A 204
GLY A 206
ILE A 332
VAL A 331
 None
 0.73A 1p2yA-5t9jA:
undetectable		 1p2yA-5t9jA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 378
TRP A 366
MET A 364
LEU A  53
 None
 1.31A 2oz7A-5t9jA:
undetectable		 2oz7A-5t9jA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A  59
GLU A  37
ASN A  55
 None
 0.82A 4imaD-5t9jA:
2.1		 4imaD-5t9jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A  59
GLU A  37
ASN A  55
 None
 0.77A 4ip7D-5t9jA:
2.0		 4ip7D-5t9jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		5 / 11 ALA A 163
ASP A 194
VAL A 331
ILE A 332
ILE A 203
 None
 1.21A 5y80A-5t9jA:
undetectable		 5y80A-5t9jA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		3 / 3 VAL A 166
TYR A 167
GLU A 136
 None
 0.90A 5zmqD-5t9jA:
undetectable
5zmqE-5t9jA:
undetectable		 5zmqD-5t9jA:
16.88
5zmqE-5t9jA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 401
LYS A 404
TYR A 456
 None
 1.20A 6gnaA-5t9jA:
undetectable		 6gnaA-5t9jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1
(Homo
sapiens) 		3 / 3 ARG A 401
LYS A 404
TYR A 456
 None
 1.20A 6gnbA-5t9jA:
undetectable		 6gnbA-5t9jA:
21.72