SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 5 ASP A 448
GLY A 508
ALA A 504
ILE A 457
 CA  A 612 (-2.5A)
None
None
None
 0.90A 2aofA-5t9tA:
undetectable		 2aofA-5t9tA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 6 SER A 453
GLY A 508
THR A 511
ARG A 505
 None
 1.16A 2f7fA-5t9tA:
undetectable		 2f7fA-5t9tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		3 / 3 SER A 403
SER A 404
HIS A 355
 MAN  A 619 (-1.4A)
None
None
 0.82A 3mzeA-5t9tA:
undetectable		 3mzeA-5t9tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		5 / 8 ASP A 131
ASP A  95
GLN A  94
PRO A   8
GLU A  63
 CA  A 603 ( 3.5A)
CA  A 602 (-3.4A)
None
None
CA  A 602 ( 2.4A)
 1.50A 3oyaA-5t9tA:
undetectable		 3oyaA-5t9tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 6 VAL A 484
LEU A 502
ILE A 461
VAL A 520
 None
 0.89A 4a9kA-5t9tA:
undetectable		 4a9kA-5t9tA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 8 ASP A  61
ASP A 186
ASN A  99
GLU A   9
 CA  A 601 (-3.5A)
CA  A 603 (-3.6A)
CA  A 601 (-4.7A)
CA  A 601 ( 2.8A)
 1.10A 4gkiE-5t9tA:
undetectable
4gkiG-5t9tA:
undetectable		 4gkiE-5t9tA:
18.91
4gkiG-5t9tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 6 GLU A 316
ASP A 343
ASP A 345
GLU A 280
 None
CA  A 609 (-2.3A)
CA  A 609 ( 3.3A)
CA  A 608 ( 2.4A)
 1.33A 4ntxA-5t9tA:
undetectable
4ntxC-5t9tA:
undetectable		 4ntxA-5t9tA:
22.52
4ntxC-5t9tA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		5 / 11 LEU A 374
ILE A 408
GLU A 360
LEU A 380
LEU A 326
 None
 1.49A 4yvpA-5t9tA:
undetectable		 4yvpA-5t9tA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 4 VAL A 406
ALA A 394
ILE A 318
THR A 341
 None
 1.08A 5e4dB-5t9tA:
undetectable		 5e4dB-5t9tA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 4 ARG A 382
ILE A 412
TYR A 388
ILE A 385
 None
 1.49A 5odhG-5t9tA:
undetectable		 5odhG-5t9tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5t9t PROTOCADHERIN GAMMA
B2-ALPHA C
(Mus
musculus) 		4 / 7 LEU A 471
VAL A 520
LEU A 500
LEU A 502
 None
 0.71A 6g9bA-5t9tA:
undetectable
6g9bB-5t9tA:
undetectable		 6g9bA-5t9tA:
11.75
6g9bB-5t9tA:
8.56