SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tbd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 TRP E 104
ASN F  39
LEU F  41
PHE F 103
 None
 0.62A 1ru9H-5tbdE:
18.9
1ru9L-5tbdE:
16.1		 1ru9H-5tbdE:
31.09
1ru9L-5tbdE:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 TRP E 104
ASN F  39
LEU F  41
PHE F 103
 None
 0.63A 1rukH-5tbdE:
19.0
1rukL-5tbdE:
16.2		 1rukH-5tbdE:
31.09
1rukL-5tbdE:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		5 / 10 HIS F  31
TYR F  37
GLY F  96
TYR E  33
HIS E  35
 None
 0.45A 2pcpC-5tbdF:
22.4
2pcpD-5tbdF:
15.1		 2pcpC-5tbdF:
75.89
2pcpD-5tbdF:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER F 105
THR F 102
PHE E  64
 None
 0.73A 2x91A-5tbdF:
undetectable		 2x91A-5tbdF:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		4 / 6 ARG F  44
PHE F  67
PRO F  64
LEU F  52
 None
 1.11A 3tgvB-5tbdF:
undetectable		 3tgvB-5tbdF:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		4 / 6 ARG F  44
PHE F  67
PRO F  64
LEU F  52
 None
 1.04A 3tgvD-5tbdF:
undetectable		 3tgvD-5tbdF:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		5 / 11 ASN F  39
LEU F  41
ARG F  51
ALA E  97
TRP E 104
 None
 0.71A 5cp3A-5tbdF:
23.4
5cp3H-5tbdF:
15.3		 5cp3A-5tbdF:
91.96
5cp3H-5tbdF:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		5 / 11 ASN F  39
LEU F  41
HIS E  35
ALA E  97
TRP E 104
 None
 0.71A 5cp3A-5tbdF:
23.4
5cp3H-5tbdF:
15.3		 5cp3A-5tbdF:
91.96
5cp3H-5tbdF:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5tbd FV FRAGMENT (MAB4D1)
HEAVY CHAIN
(Mus
musculus) 		5 / 12 PHE F 103
THR E  58
ARG E  50
GLY E  49
ILE E  48
 None
 1.14A 5ifuA-5tbdF:
undetectable		 5ifuA-5tbdF:
11.65